scholarly journals Development of Palladium-catalyzed Cycloalkenylation and its Application to Bioactive Natural Product Synthesis

2014 ◽  
Vol 13 ◽  
pp. 3-12
Author(s):  
Masahiro Toyora
Keyword(s):  
Natural Product ◽  
Natural Product Synthesis ◽  
Palladium Catalyzed ◽  
Bioactive Natural Product

scholarly journals Development of a Second Generation Palladium-Catalyzed Cycloalkenylation and its Application to Bioactive Natural Product Synthesis

2013 ◽  
Vol 8 (7) ◽  
pp. 1934578X1300800
Author(s):  
Masahiro Toyota
Keyword(s):  
Natural Product ◽  
Second Generation ◽  
Natural Product Synthesis ◽  
Total Syntheses ◽  
Palladium Catalyzed ◽  
Oxidative Alkylation ◽  
Bioactive Natural Product

A novel palladium-catalyzed intramolecular oxidative alkylation of unactivated olefins is described. This protocol was devised to solve one of the drawbacks of the original palladium-catalyzed cycloalkenylation that we developed. We call this new procedure the ‘second generation palladium-catalyzed cycloalkenylation’. This protocol has been applied to the total syntheses of cis-195A trans-195A boonein scholareins A C D and α-skytanthine.

Palladium-catalyzed cascade cyclizations involving C–C and C–X bond formation: strategic applications in natural product synthesis

2021 ◽  
Author(s):  
K. R. Holman ◽  
A. M. Stanko ◽  
S. E. Reisman
Keyword(s):  
Natural Product ◽  
Bond Formation ◽  
Natural Product Synthesis ◽  
Cascade Cyclizations ◽  
Palladium Catalyzed ◽  
Multiple Rings

This tutorial review highlights the use of palladium-catalyzed cascade cyclizations in natural product synthesis, focusing on cascades that construct multiple rings and form both C–C and C–X (X = O, N) bonds in a single synthetic operation.

Palladium-catalyzed asymmetric dearomative cyclization in natural product synthesis

2020 ◽  
Vol 18 (23) ◽  
pp. 4354-4370
Author(s):  
Zhuo Wang
Keyword(s):  
Natural Product ◽  
Natural Product Synthesis ◽  
Palladium Catalyzed

This review discusses palladium-catalyzed asymmetric dearomative cyclization, which is invaluable for producing enantioenriched materials, for complex natural product synthesis.

Methodology for stereochemical control in bioactive natural product synthesis - new methods toward enediyne antitumor antibiotics

1990 ◽  
Vol 62 (10) ◽  
pp. 2007-2012 ◽  
Author(s):  
M. Isobe ◽  
T. Nishikawa ◽  
Angkana Herunsalee ◽  
T. Tsukiyama ◽  
Yumi Hirose ◽  
...  
Keyword(s):  
Natural Product ◽  
Natural Product Synthesis ◽  
Antitumor Antibiotics ◽  
New Methods ◽  
Stereochemical Control ◽  
Bioactive Natural Product

Enantioselective palladium catalyzed conjugate additions of ortho-substituted arylboronic acids to β,β-disubstituted cyclic enones: total synthesis of herbertenediol, enokipodin A and enokipodin B

2014 ◽  
Vol 12 (31) ◽  
pp. 5883-5890 ◽  
Author(s):  
Jeffrey Buter ◽  
Renée Moezelaar ◽  
Adriaan J. Minnaard
Keyword(s):  
Total Synthesis ◽  
Natural Product ◽  
Conjugate Addition ◽  
Natural Product Synthesis ◽  
Conjugate Additions ◽  
Arylboronic Acids ◽  
Cyclic Enones ◽  
Palladium Catalyzed

Palladium catalyzed asymmetric conjugate addition of ortho-substituted arylboronic acids to cyclic enones and its application in natural product synthesis.

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