Freehand-SPECT with 99mTc-HDP as tool to guide percutaneous biopsy of skeletal lesions detected on bone scintigraphy

Abstract Background Assessment of lymphatic status via sentinel lymph node (SLN) biopsy is an integral and crucial part of melanoma surgical oncology. The most common technique for sentinel node mapping is preoperative planar scintigraphy of an injected gamma-emitting lymphatic tracer followed by intraoperative node localization using a non-imaging gamma probe with auditory feedback. In recent years, intraoperative visualization of SLNs in 3D has become possible by coupling the probe to an external system capable of tracking its location and orientation as it is read out, thereby enabling computation of the 3D distribution of the tracer (freehand SPECT). In this project, the non-imaging probe of the fhSPECT system was replaced by a unique handheld gamma camera containing an array of sodium iodide crystals optically coupled to an array of silicon photomultipliers (SiPMs). A feasibility study was performed in which preoperative SLN mapping was performed using camera fhSPECT and the number of detected nodes was compared to that visualized by lymphoscintigraphy, probe fhSPECT, and to the number ultimately excised under non-imaging probe guidance. Results Among five subjects, SLNs were detected in nine lymphatic basins, with one to five SLNs detected per basin. A basin-by-basin comparison showed that the number of SLNs detected using camera fhSPECT exceeded that using lymphoscintigraphy and probe fhSPECT in seven of nine basins and five of five basins, respectively. (Probe fhSPECT scans were not performed for four basins.) It exceeded the number excised under non-imaging probe guidance for seven of nine basins and equaled the number excised for the other two basins. Conclusions Freehand SPECT using a prototype SiPM-based gamma camera demonstrates high sensitivity for detection of SLNs in a preoperative setting. Camera fhSPECT is a potential means for efficiently obtaining real-time 3D activity distribution maps in applications such as image-guided percutaneous biopsy, and surgical SLN biopsy or radioguided tumor excision.

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Percutaneous biopsy of skeletal lesions.

American Journal of Roentgenology ◽

10.2214/ajr.157.5.1927811 ◽

1991 ◽

Vol 157 (5) ◽

pp. 935-942 ◽

Cited By ~ 49

Author(s):

S V Kattapuram ◽

D I Rosenthal

Keyword(s):

Percutaneous Biopsy ◽

Skeletal Lesions

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Percutaneous biopsy of musculo-skeletal lesions

Interventional Radiology in Bone and Joint ◽

10.1007/978-3-7091-8948-1_1 ◽

1988 ◽

pp. 3-50

Author(s):

J.-D. Laredo ◽

M. Bard ◽

Charlotte Cywiner-Golenzer ◽

J. Chretien

Keyword(s):

Percutaneous Biopsy ◽

Skeletal Lesions

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Evaluation of Camera-Based Freehand SPECT in Preoperative Sentinel Lymph Node Mapping for Melanoma Patients

10.21203/rs.3.rs-31009/v1 ◽

2020 ◽

Author(s):

Annie K. Kogler ◽

Andrew M. Polemi ◽

Surabhi Nair ◽

Stanislaw Majewski ◽

Lynn E. Dengel ◽

...

Keyword(s):

Lymph Node ◽

Sentinel Lymph Node ◽

Gamma Camera ◽

Gamma Probe ◽

Percutaneous Biopsy ◽

Silicon Photomultiplier ◽

Imaging Probe ◽

Lymph Node Mapping ◽

Distribution Maps ◽

Freehand Spect

Abstract Background Assessment of lymphatic status via sentinel lymph node (SLN) biopsy is an integral and crucial part of melanoma surgical oncology. The most common technique for sentinel node mapping is preoperative planar scintigraphy of an injected gamma-emitting lymphatic tracer followed by intraoperative node localization using a non-imaging gamma probe with auditory feedback. In recent years, intraoperative visualization of SLNs in 3-D has become possible by coupling the probe to an external system capable of tracking its location and orientation as it is read out, thereby enabling computation of the 3D distribution of the tracer (freehand SPECT). In this project, the non-imaging probe of the fhSPECT system was replaced by a unique handheld gamma camera containing an array of sodium iodide crystals optically coupled to an array of silicon photomultipliers. A feasibility study was performed in which preoperative SLN mapping was performed using camera fhSPECT and the number of detected nodes was compared to that visualized by lymphoscintigraphy, probe fhSPECT, and to the number ultimately excised under non-imaging probe guidance.Results Among five subjects, SLNs were detected in nine lymphatic basins, with one to five SLNs detected per basin. A basin-by-basin comparison showed that the number of SLNs detected using camera fhSPECT exceeded that using lymphoscintigraphy and probe fhSPECT in seven of nine basins and five of five basins, respectively (probe fhSPECT scans were not performed for four basins). It exceeded the number excised under non-imaging probe guidance for seven of nine basins. There were no basins for which the number of excised nodes exceeded the number detected by camera fhSPECT. Conclusions Freehand SPECT using a prototype silicon photomultiplier-based gamma camera demonstrates high sensitivity for detection of SLNs in a preoperative setting. Camera fhSPECT is a potential means for efficiently obtaining real-time 3D activity distribution maps in applications such as image-guided percutaneous biopsy, and surgical SLNB or radioguided tumor excision.

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DETERMINATION OF TIME OF ONSET AND LOCATION OF EARLY SKELETAL LESIONS IN YOUNG DOGS EXPERIMENTALLY INFECTED WITH HEPATOZOON AMERICANUM USING BONE SCINTIGRAPHY

Veterinary Radiology & Ultrasound ◽

10.1111/j.1740-8261.2003.tb01455.x ◽

2003 ◽

Vol 44 (1) ◽

pp. 86-91 ◽

Cited By ~ 7

Author(s):

Wm Tod Drosty ◽

Connie A. Cummings ◽

J.S. Mathew ◽

Roger J. Panciera ◽

C.H. KO Jeff

Keyword(s):

Bone Scintigraphy ◽

Hepatozoon Americanum ◽

Skeletal Lesions

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Evaluation of Camera-Based Freehand SPECT in Preoperative Sentinel Lymph Node Mapping for Melanoma Patients

10.21203/rs.3.rs-31009/v2 ◽

2020 ◽

Author(s):

Annie K. Kogler ◽

Andrew M. Polemi ◽

Surabhi Nair ◽

Stanislaw Majewski ◽

Lynn E. Dengel ◽

...

Keyword(s):

Lymph Node ◽

Sentinel Lymph Node ◽

Gamma Camera ◽

Gamma Probe ◽

Percutaneous Biopsy ◽

Sentinel Lymph Node Mapping ◽

Imaging Probe ◽

Lymph Node Mapping ◽

Distribution Maps ◽

Freehand Spect

Abstract Background Assessment of lymphatic status via sentinel lymph node (SLN) biopsy is an integral and crucial part of melanoma surgical oncology. The most common technique for sentinel node mapping is preoperative planar scintigraphy of an injected gamma-emitting lymphatic tracer followed by intraoperative node localization using a non-imaging gamma probe with auditory feedback. In recent years, intraoperative visualization of SLNs in 3-D has become possible by coupling the probe to an external system capable of tracking its location and orientation as it is read out, thereby enabling computation of the 3D distribution of the tracer (freehand SPECT). In this project, the non-imaging probe of the fhSPECT system was replaced by a unique handheld gamma camera containing an array of sodium iodide crystals optically coupled to an array of silicon photomultipliers (SiPMs). A feasibility study was performed in which preoperative SLN mapping was performed using camera fhSPECT and the number of detected nodes was compared to that visualized by lymphoscintigraphy, probe fhSPECT, and to the number ultimately excised under non-imaging probe guidance.Results Among five subjects, SLNs were detected in nine lymphatic basins, with one to five SLNs detected per basin. A basin-by-basin comparison showed that the number of SLNs detected using camera fhSPECT exceeded that using lymphoscintigraphy and probe fhSPECT in seven of nine basins and five of five basins, respectively (probe fhSPECT scans were not performed for four basins). It exceeded the number excised under non-imaging probe guidance for seven of nine basins, and equaled the number excised for the other two basins. Conclusions Freehand SPECT using a prototype SiPM-based gamma camera demonstrates high sensitivity for detection of SLNs in a preoperative setting. Camera fhSPECT is a potential means for efficiently obtaining real-time 3D activity distribution maps in applications such as image-guided percutaneous biopsy, and surgical SLN biopsy or radioguided tumor excision.

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Evaluation of Camera-Based Freehand SPECT in Preoperative Sentinel Lymph Node Mapping for Melanoma Patients

10.21203/rs.3.rs-31009/v3 ◽

2020 ◽

Author(s):

Annie K. Kogler ◽

Andrew M. Polemi ◽

Surabhi Nair ◽

Stanislaw Majewski ◽

Lynn E. Dengel ◽

...

Keyword(s):

Lymph Node ◽

Sentinel Lymph Node ◽

Gamma Camera ◽

Gamma Probe ◽

Percutaneous Biopsy ◽

Sentinel Lymph Node Mapping ◽

Imaging Probe ◽

Lymph Node Mapping ◽

Distribution Maps ◽

Freehand Spect

Abstract BackgroundAssessment of lymphatic status via sentinel lymph node (SLN) biopsy is an integral and crucial part of melanoma surgical oncology. The most common technique for sentinel node mapping is preoperative planar scintigraphy of an injected gamma-emitting lymphatic tracer followed by intraoperative node localization using a non-imaging gamma probe with auditory feedback. In recent years, intraoperative visualization of SLNs in 3-D has become possible by coupling the probe to an external system capable of tracking its location and orientation as it is read out, thereby enabling computation of the 3D distribution of the tracer (freehand SPECT). In this project, the non-imaging probe of the fhSPECT system was replaced by a unique handheld gamma camera containing an array of sodium iodide crystals optically coupled to an array of silicon photomultipliers (SiPMs). A feasibility study was performed in which preoperative SLN mapping was performed using camera fhSPECT and the number of detected nodes was compared to that visualized by lymphoscintigraphy, probe fhSPECT, and to the number ultimately excised under non-imaging probe guidance.ResultsAmong five subjects, SLNs were detected in nine lymphatic basins, with one to five SLNs detected per basin. A basin-by-basin comparison showed that the number of SLNs detected using camera fhSPECT exceeded that using lymphoscintigraphy and probe fhSPECT in seven of nine basins and five of five basins, respectively (probe fhSPECT scans were not performed for four basins). It exceeded the number excised under non-imaging probe guidance for seven of nine basins, and equaled the number excised for the other two basins. ConclusionsFreehand SPECT using a prototype SiPM-based gamma camera demonstrates high sensitivity for detection of SLNs in a preoperative setting. Camera fhSPECT is a potential means for efficiently obtaining real-time 3D activity distribution maps in applications such as image-guided percutaneous biopsy, and surgical SLN biopsy or radioguided tumor excision.

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Ultrasound-guided percutaneous biopsy for the diagnosis of gastrointestinal masses

Ultraschall in der Medizin - European Journal of Ultrasound ◽

10.1055/s-0033-1354846 ◽

2013 ◽

Vol 34 (S 01) ◽

Author(s):

A Funaro ◽

LM Vitale ◽

M Niosi ◽

D Sgambato ◽

A Del Prete ◽

...

Keyword(s):

Percutaneous Biopsy ◽

Ultrasound Guided

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Scintigraphy with 99m Tc-Phosphonate and 67Gallium in Patients Suspected of Primary Bone Tumors

Nuklearmedizin ◽

10.1055/s-0037-1620567 ◽

1982 ◽

Vol 21 (04) ◽

pp. 136-139 ◽

Cited By ~ 2

Author(s):

C.-J. Edeling

Keyword(s):

Soft Tissue ◽

Bone Scintigraphy ◽

Primary Tumor ◽

Bone Tumors ◽

Whole Body ◽

Skeletal Metastases ◽

Malignant Bone Tumors ◽

67Ga Scintigraphy ◽

Primary Bone Tumors ◽

Primary Bone

Whole-body scintigraphy with both 99mTc-phosphonate and 67Ga was performed on 92 patients suspected of primary bone tumors. In 46 patients with primary malignant bone tumors, scintigraphy with 99mTc-phosphonate disclosed the primary tumor in 44 cases and skeletal metastases in 11, and 67Ga scintigraphy detected the primary tumor in 43 cases, skeletal metastases in 6 cases and soft-tissue metastases in 8 cases. In 25 patients with secondary malignant bone tumors, bone scintigraphy visualized a single lesion in 10 cases and several lesions in 15 cases, and 67Ga scintigraphy detected the primary tumor in 17 cases, skeletal metastases in 17 cases and soft-tissue metastases in 9 cases. In 21 patients with benign bone disease positive uptake of 99mTc-phosphonate was recognized in 19 cases and uptake of 67Ga in 17 cases. It is concluded that bone scintigraphy should be used in patients suspected of primary bone tumors. If malignancy is suspected, 67Ga scintigraphy should be performed in addition.

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