Combined repeated dose and reproductive/developmental toxicity screening test of cerium oxide nanoparticles in rats

2016 ◽  
Vol 64 ◽  
pp. 36
Author(s):  
Jinsoo Lee ◽  
Wook-Joon Yu ◽  
Ji-Seong Jeong ◽  
Kwangsik Park ◽  
Juyoung Park ◽  
...  
Keyword(s):  
Cerium Oxide ◽  
Screening Test ◽  
Developmental Toxicity ◽  
Repeated Dose ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Toxicity Screening

scholarly journals Safety assessment of cerium oxide nanoparticles: Combined repeated-dose toxicity with reproductive/developmental toxicity screening and biodistribution in rats

2019 ◽  
Author(s):  
Jinsoo Lee ◽  
Ji-Seong Jeong ◽  
Sang Yun Kim ◽  
Seung-Jin Lee ◽  
Young-Jun Shin ◽  
...  
Keyword(s):  
Cerium Oxide ◽  
Safety Assessment ◽  
Developmental Toxicity ◽  
Real Life ◽  
Repeated Dose ◽  
Oral Exposure ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Toxicity Screening ◽  
Sprague Dawley

Abstract Background Cerium oxide nanoparticles (CeO 2 NPs) are widely used in various commercial applications because of their characteristic properties. CeO 2 NPs can be easily exposed to humans in real life, but the safety assessment of CeO 2 NPs has not been fully investigated. Therefore, in this study, we conducted a combined repeated-dose and reproductive/developmental toxicity screening study to investigate the potential effects on general health hazards, including reproductive/developmental functions, after repeated CeO 2 NPs oral exposure. In addition, tissues from parental animals and their pups were collected to analyze the internal accumulation of cerium. CeO 2 NPs were orally administered to Sprague-Dawley rats at doses of 0, 100, 300 and 1000 mg/kg during their pre-mating, mating, gestation and early lactation periods. Results In the general systemic and reproductive/developmental examinations, no marked toxicities were observed in any of in-life and terminal observation parameters in this study. In the biodistribution analysis, cerium was not detected in either parental or pup tissues (blood, liver, lungs and kidneys). Conclusion Repeated oral exposure of CeO 2 NPs did not induce marked toxicities affecting general systemic and reproductive/developmental functions up to the dose level of 1000 mg/kg and the CeO 2 NPs were not systemically absorbed in parental animals or their pups. This result could be used to risk assessment for human, and additional toxicity studies with CeO 2 NPs will be necessary considering various physicochemical properties and exposure probabilities of this nanoparticles.

scholarly journals Combined repeated-dose and reproductive/developmental toxicity screening test of 3-amino-5-mercapto-1,2,4-triazole in rats

2013 ◽  
Vol 38 (5) ◽  
pp. 759-773 ◽  
Author(s):  
Junichi Kikuchi ◽  
Sunao Aso ◽  
Takayuki Koga ◽  
Katsumi Miyata ◽  
Satsuki Hoshuyama ◽  
...  
Keyword(s):  
Screening Test ◽  
Developmental Toxicity ◽  
Repeated Dose ◽  
Toxicity Screening

scholarly journals Combined repeated dose and reproductive/developmental toxicity screening test of tert-butylhydrazine monohydrochloride in rats

2013 ◽  
Vol 38 (2) ◽  
pp. 177-192 ◽  
Author(s):  
Toshio Kobayashi ◽  
Sunao Aso ◽  
Takayuki Koga ◽  
Satsuki Hoshuyama ◽  
Yutaka Oshima ◽  
...  
Keyword(s):  
Screening Test ◽  
Developmental Toxicity ◽  
Repeated Dose ◽  
Toxicity Screening

Combined repeated-dose and reproductive/developmental toxicity screening test of benzene, 1,1′-oxybis-, tetrapropylene derivs. in rats

2017 ◽  
Vol 41 (4) ◽  
pp. 492-500
Author(s):  
Yasuhiro Tsubokura ◽  
Ryuichi Hasegawa ◽  
Sunao Aso ◽  
Toshio Kobayashi ◽  
Takayuki Koga ◽  
...  
Keyword(s):  
Screening Test ◽  
Developmental Toxicity ◽  
Repeated Dose ◽  
Toxicity Screening

Combined repeated-dose toxicity study of silver nanoparticles with the reproduction/developmental toxicity screening test

2013 ◽  
Vol 8 (4) ◽  
pp. 349-362 ◽  
Author(s):  
Jeong-Sup Hong ◽  
Suhyon Kim ◽  
Sang Hee Lee ◽  
Eunhye Jo ◽  
Byungcheun Lee ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Screening Test ◽  
Developmental Toxicity ◽  
Toxicity Study ◽  
Repeated Dose ◽  
Toxicity Screening ◽  
Repeated Dose Toxicity
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