safety assessment
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2022 ◽  
Vol 31 ◽  
pp. 100780
M.D. Marazuela ◽  
M. Klaiber ◽  
E. Moreno-Gordaliza ◽  
A. Barata ◽  
M.M. Gómez-Gómez

2022 ◽  
Vol 10 (1) ◽  
pp. 022-032
Okol Sri Suharyo ◽  
Ayip Rivai Prabowo ◽  
Mardi Winoelyo

Surabaya East Shipping Channel is part of the busiest shipping lanes west of Surabaya in Indonesia after inflows in Tanjung Priok. With the navigation, channel conditions are long and narrow plus the number of flows in and out of the harbor boats is very vulnerable to accidents resulting in either the stranded sea, ship collision, or other accident types, which would harm the cruise interocular. By looking at the facts above, so it is necessary to conduct a more in-depth study of the accident risk assessment of the shipping channel east of Surabaya. This study aimed to obtain any kind of accident that has a high risk in the port of Surabaya, to know what impact may result from an accident with a high risk and gain steps that can be taken to reduce accidents in Surabaya East Shipping Channel by using Method Formal Safety Assessment (FSA). Of the six types of accidents that occur, there are three accidents with the highest risk of stranded ships, human accidents, collisions with ships dock at the time of sailing ships and dock. The impact of the third accident caused huge material losses. To reduce the risk of all three types of accidents was measured Implied Cost of Averting a Risk (ICAR), the lowest of any risk reduction options. Reduction of risk to do is impose a routine patrol and installation of signs groove ICAR ports have amounted to 234 million, giving a human rescue training vessel which has a value of 112 million ICAR and the latter is tightened harbor area with ICAR 84 million so that unauthorized parties do not enter in the harbor area.

Energies ◽  
2022 ◽  
Vol 15 (2) ◽  
pp. 521
Gyunyoung Heo

Since the publication of the first comprehensive Probabilistic Safety Assessment (PSA) study—known as WASH-1400—in the US, PSA has developed into an effective and systematic method of identifying hazards, and evaluating and prioritizing the risks in nuclear facilities [...]

2022 ◽  
Vol 10 (4) ◽  
Daniele Pattono ◽  
Alessandra Dalmasso ◽  
Pier Giorgio Peiretti ◽  
Francesco Gai ◽  
Maria Teresa Bottero

Traditional foods are gaining more and more market due to consumers’ increasing willingness to buy products linked to national cultures: among these products, cheese plays an important role. Plaisentif is a traditional Piedmont cheese, only made during violets blooming season. The aim of this work is to evaluate the safety of this cheese, taking into account the EU Regulations. Microbiological hazards as well chemical, biogenic amines and mycotoxins, analysis were investigated. Salmonella spp. and Listeria monocytogenes were never detected in cheeses after ripening. Biogenic amines were present in very low quantities. Ochratoxin A was never detected and patulin was detected in over one cheese during the two years of sampling. This is the first attempt to characterize traditional Plaisentif cheese from a safety point of view. All the information acquired can be held as a necessary basis for reinforcing the culture of traditional products, for economic opportunities in mountainous regions and for safeguarding traditions and cultural identities.

Shining Wang ◽  
Grace Chen ◽  
Emilio Merlo Pich ◽  
John Affinito ◽  
Michael Cwik ◽  

A. Yu. Savchenko ◽  
G. V. Ramenskaya ◽  
V. G. Kukes ◽  
M. S. Burenkov ◽  
B. V. Shilov

Relevance. In connection with the increase in the number of cases of multidrug-resistant tuberculosis (MDR-TB), the search for new anti-tuberculosis drugs (ATD) is necessary. The assessment of its effect on the human body outside the aspect of the therapeutic effect is one of the main directions in the development of anti-TB drugs.Aim. Evaluation of the possible toxicity of thiosonide, a new domestic anti-TB drug, combining a consistent study of this side of the drug using a bioinformatics approach and an analysis of the results of a clinical safety study.Methods. The bioinformatic assessment was carried out using web services and models to predict the toxicity of thiosonide. The safety assessment in relation to healthy volunteers was carried out as part of a clinical study according to the protocol: «An open-label study of the pharmacokinetics, safety and tolerability of the drug thiozonide, capsule 100 mg with a single dose of increasing doses by various groups of healthy volunteers.» (2013, Permit No. 187 to conduct a clinical trial dated March 22, 2013, issued by the Ministry of Health of the Russian Federation).Results. Potential unwanted targets were identified, the predicted activity value for which was greater than 7. The results obtained indicate the likelihood of the effect of thiosonide on these protein targets and, possibly, the ability of the latter to cause side effects associated with changes in the activity of these molecules. The cytotoxic and carcinogenic effect of thiosonide is not predicted. During a clinical study, the drug thiosonide showed good tolerance and safety, since the identified adverse events did not show a definite or reliable relationship with the study drug. The resolution of all adverse events was complete, and dose escalation did not affect the number, severity of AEs and association with the study drug.Conclusion. The safety analysis of thiosonide demonstrated its good tolerability both during in silico assessment and in a study with the participation of healthy volunteers.

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