Vertebroplasty Associated with a Lower Risk of Mortality and Morbidity of Aged Patients with Painful Vertebral Compression Fractures: A Population-Based Propensity Score Matching Cohort Study in Taiwan

AbstractBackgroundIn this territory-wide, observational, propensity score-matched cohort study, we evaluate the development of transient ischaemic attack and ischaemic stroke (TIA/Ischaemic stroke) in patients with AF treated with edoxaban or warfarin.MethodsThis was an observational, territory-wide cohort study of patients between January 1st, 2016 and December 31st, 2019, in Hong Kong. The inclusion were patients with i) atrial fibrillation, and ii) edoxaban or warfarin prescription. 1:2 propensity score matching was performed between edoxaban and warfarin users. Univariate Cox regression identifies significant risk predictors of the primary, secondary and safety outcomes. Hazard ratios (HRs) with corresponding 95% confidence interval [CI] and p values were reported.ResultsThis cohort included 3464 patients (54.18% males, median baseline age: 72 years old, IQR: 63-80, max: 100 years old), 664 (19.17%) with edoxaban use and 2800 (80.83%) with warfarin use. After a median follow-up of 606 days (IQR: 306-1044, max: 1520 days), 91(incidence rate: 2.62%) developed TIA/ischaemic stroke: 1.51% (10/664) in the edoxaban group and 2.89% (81/2800) in the warfarin group. Edoxaban was associated with a lower risk of TIA or ischemic stroke when compared to warfarin.ConclusionsEdoxaban use was associated with a lower risk of TIA or ischemic stroke after propensity score matching for demographics, comorbidities and medication use.

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Spinal or general anaesthesia for surgical repair of hip fracture and subsequent risk of mortality and morbidity: a database analysis using propensity score‐matching

Anaesthesia ◽

10.1111/anae.15042 ◽

2020 ◽

Vol 75 (9) ◽

pp. 1173-1179 ◽

Cited By ~ 1

Author(s):

L. Morgan ◽

T. M. McKeever ◽

J. Nightingale ◽

D. E. Deakin ◽

I. K. Moppett

Keyword(s):

Hip Fracture ◽

Propensity Score ◽

Propensity Score Matching ◽

General Anaesthesia ◽

Surgical Repair ◽

Database Analysis ◽

Mortality And Morbidity ◽

Risk Of Mortality ◽

Subsequent Risk

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Association between Hydroxychloroquine and bacterial pneumonia in rheumatic patients: A population‐based propensity score matching cohort study

International Journal of Clinical Practice ◽

10.1111/ijcp.14737 ◽

2021 ◽

Author(s):

Shih‐Yi Lin ◽

Cheng‐Li Lin ◽

Shih‐Sheng Chang ◽

Wu‐Huei Hsu ◽

Cheng‐Chieh Lin ◽

...

Keyword(s):

Cohort Study ◽

Propensity Score ◽

Propensity Score Matching ◽

Bacterial Pneumonia ◽

Population Based ◽

Rheumatic Patients

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Preexisting Dementia Is Associated with Increased Risks of Mortality and Morbidity Following Major Surgery: A Nationwide Propensity Score Matching Study

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17228431 ◽

2020 ◽

Vol 17 (22) ◽

pp. 8431

Author(s):

Yu-Ming Wu ◽

Hsien-Cheng Kuo ◽

Chun-Cheng Li ◽

Hsiang-Ling Wu ◽

Jui-Tai Chen ◽

...

Keyword(s):

Propensity Score ◽

Propensity Score Matching ◽

Senile Dementia ◽

Major Surgery ◽

Perioperative Mortality ◽

Mortality And Morbidity ◽

Dementia Patients ◽

Risk Of Mortality ◽

Clinical Covariates ◽

Physiological Abnormalities

Patients with dementia are predisposed to multiple physiological abnormalities. It is uncertain if dementia associates with higher rates of perioperative mortality and morbidity. We used reimbursement claims data of Taiwan’s National Health Insurance and conducted propensity score matching analyses to evaluate the risk of mortality and major complications in patients with or without dementia undergoing major surgery between 2004 and 2013. We applied multivariable logistic regressions to calculate adjusted odds ratios (aORs) with 95% confidence intervals (CIs) for the outcome of interest. After matching to demographic and clinical covariates, 7863 matched pairs were selected for analysis. Dementia was significantly associated with greater risks of 30-day in-hospital mortality (aOR: 1.71, 95% CI: 1.09–2.70), pneumonia (aOR: 1.48, 95% CI: 1.16–1.88), urinary tract infection (aOR: 1.59, 95% CI: 1.30–1.96), and sepsis (OR: 1.77, 95% CI: 1.34–2.34) compared to non-dementia controls. The mortality risk in dementia patients was attenuated but persisted over time, 180 days (aOR: 1.49, 95% CI: 1.23–1.81) and 365 days (aOR: 1.52, 95% CI: 1.30–1.78) after surgery. Additionally, patients with dementia were more likely to receive blood transfusion (aOR: 1.32, 95% CI: 1.11–1.58) and to need intensive care (aOR: 1.40, 95% CI: 1.12–1.76) compared to non-dementia controls. Senile dementia and Alzheimer’s disease were independently associated with higher rates of perioperative mortality and complications, but vascular dementia was not affected. We found that preexisting dementia was associated with mortality and morbidity after major surgery.

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