scholarly journals CRISPR/Cas9 editing of directly reprogrammed myogenic progenitors restores dystrophin expression in a mouse model of muscular dystrophy

2022 ◽  
Author(s):  
Seraina A. Domenig ◽  
Nicola Bundschuh ◽  
Ajda Lenardič ◽  
Adhideb Ghosh ◽  
Inseon Kim ◽  
...  
Keyword(s):  
Muscular Dystrophy ◽  
Mouse Model ◽  
Dystrophin Expression

Nanopatterned muscle cell patches for enhanced myogenesis and dystrophin expression in a mouse model of muscular dystrophy

Biomaterials ◽  
2014 ◽  
Vol 35 (5) ◽  
pp. 1478-1486 ◽  
Author(s):  
Hee Seok Yang ◽  
Nicholas Ieronimakis ◽  
Jonathan H. Tsui ◽  
Hong Nam Kim ◽  
Kahp-Yang Suh ◽  
...  
Keyword(s):  
Muscular Dystrophy ◽  
Mouse Model ◽  
Muscle Cell ◽  
Dystrophin Expression

scholarly journals Postnatal genome editing partially restores dystrophin expression in a mouse model of muscular dystrophy

Science ◽  
2015 ◽  
Vol 351 (6271) ◽  
pp. 400-403 ◽  
Author(s):  
C. Long ◽  
L. Amoasii ◽  
A. A. Mireault ◽  
J. R. McAnally ◽  
H. Li ◽  
...  
Keyword(s):  
Muscular Dystrophy ◽  
Mouse Model ◽  
Genome Editing ◽  
Dystrophin Expression

scholarly journals Read-through compound 13 restores dystrophin expression and improves muscle function in the mdx mouse model for Duchenne muscular dystrophy

2012 ◽  
Vol 21 (18) ◽  
pp. 4007-4020 ◽  
Author(s):  
Refik Kayali ◽  
Jin-Mo Ku ◽  
Gregory Khitrov ◽  
Michael E. Jung ◽  
Olga Prikhodko ◽  
...  
Keyword(s):  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Mouse Model ◽  
Muscle Function ◽  
Mdx Mouse ◽  
Dystrophin Expression

Regenerating myofibers in tibialis anterior muscles of young ‘MDX’ mice

1987 ◽  
Vol 45 ◽  
pp. 726-727
Author(s):  
H. D. Geissinge ◽  
L.D. Rhodes
Keyword(s):  
Muscular Dystrophy ◽  
Mouse Model ◽  
Tibialis Anterior ◽  
Physiological Activity ◽  
Mdx Mice ◽  
Mode Of Inheritance

A recently discovered mouse model (‘mdx’) for muscular dystrophy in man may be of considerable interest, since the disease in ‘mdx’ mice is inherited by the same mode of inheritance (X-linked) as the human Duchenne (DMD) muscular dystrophy. Unlike DMD, which results in a situation in which the continual muscle destruction cannot keep up with abortive regenerative attempts of the musculature, and the sufferers of the disease die early, the disease in ‘mdx’ mice appears to be transient, and the mice do not die as a result of it. In fact, it has been reported that the severely damaged Tibialis anterior (TA) muscles of ‘mdx’ mice seem to display exceptionally good regenerative powers at 4-6 weeks, so much so, that these muscles are able to regenerate spontaneously up to their previous levels of physiological activity.

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