Observational versus antibiotic therapy for acute uncomplicated diverticulitis: A non-inferiority meta-analysis based on a Delphi consensus

Surgery ◽  
2021 ◽  
Author(s):  
Richard Garfinkle ◽  
Ebram Salama ◽  
Alexandre Amar-Zifkin ◽  
Nancy Morin ◽  
Gabriela Ghitulescu ◽  
...  
Keyword(s):  
Antibiotic Therapy ◽  
Meta Analysis ◽  
Delphi Consensus ◽  
Uncomplicated Diverticulitis ◽  
Acute Uncomplicated Diverticulitis

Observational Therapy for Acute Uncomplicated Diverticulitis: Noninferiority Meta-Analysis Based on Delphi Consensus

2020 ◽  
Vol 231 (4) ◽  
pp. S60-S61
Author(s):  
Richard Garfinkle ◽  
Ebram Salama ◽  
Nancy Morin ◽  
Gabriela Ghitulescu ◽  
Julio Faria ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Delphi Consensus ◽  
Uncomplicated Diverticulitis ◽  
Acute Uncomplicated Diverticulitis

scholarly journals 321 Role of Antibiotics in Acute uncomplicated diverticulitis, A Systematic Review and Meta-Analysis

2021 ◽  
Vol 108 (Supplement_2) ◽  
Author(s):  
A A Tahir ◽  
K M Ali ◽  
A U Khan ◽  
S Kamal ◽  
A Hussain ◽  
...  
Keyword(s):  
Systematic Review ◽  
Statistical Analysis ◽  
Treatment Failure ◽  
Hospital Stay ◽  
Meta Analysis ◽  
Dietary Advice ◽  
Duration Of Hospital Stay ◽  
Uncomplicated Diverticulitis ◽  
Acute Uncomplicated Diverticulitis

Abstract Introduction Diverticular disease is a common health problem with a wide clinical spectrum. About 75% of the patients would have uncomplicated diverticulitis. Cornerstones of treatment are antibiotics, analgesia, and dietary advice. Recent evidence has shown that its treatment is controversial, questioning the use of antibiotics. Aim is to assess the role of antibiotics in the treatment of acute uncomplicated diverticulitis. Method This is a systematic review and Meta-analysis. Literature review of the available studies was conducted using search engines like Pubmed, Medline, Embase, Google Scholar, and Cochrane databases. Statistical analysis was conducted using RevMan5.4. Results Out of 1754 records 1324 were duplicates, 430 studies were screened. 395 were further excluded.35 full text articles were assessed and in the final review 10 studies were included. PRISMA guidelines were used. Pooled OR for recurrence = 0.92 (95% CI = 0.74 to 1.13). Pooled OR for Hospital stay= -0.66 (95% CI= -1.12 to -0.21). Pooled OR for complications = 1.06 (95% CI = 0.69 to 1.64). Pooled OR for treatment failure= 1.24 (95% CI = 0.90-1.69). Conclusions We conclude that from the available evidence antibiotics have no role in reducing recurrence, complications, treatment failure, and duration of hospital stay in acute uncomplicated diverticulitis.

The role of antibiotics in acute uncomplicated diverticulitis: A systematic review and meta-analysis

2018 ◽  
Vol 216 (3) ◽  
pp. 604-609 ◽  
Author(s):  
Valentin Mocanu ◽  
Jerry T. Dang ◽  
Noah Switzer ◽  
Iran Tavakoli ◽  
Chunhong Tian ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Uncomplicated Diverticulitis ◽  
Acute Uncomplicated Diverticulitis

scholarly journals Antibiotics for acute uncomplicated diverticulitis in hospitalized patients

Medwave ◽  
2021 ◽  
Vol 21 (02) ◽  
pp. e8140-e8140
Author(s):  
Cristóbal Araya-Quezada ◽  
Lídice Torres-Bavestrello ◽  
Gustavo Gómez-Barbieri ◽  
Alejandro Zárate-Castillo
Keyword(s):  
Systematic Reviews ◽  
Randomized Clinical Trials ◽  
Acute Diverticulitis ◽  
Meta Analysis ◽  
Hospitalized Patients ◽  
Summary Table ◽  
Uncomplicated Diverticulitis ◽  
Urgent Surgery ◽  
Grade Methodology ◽  
Acute Uncomplicated Diverticulitis

Introduction Acute diverticulitis is one of the complications of diverticular disease. Nowadays, there is a paradigm shift regarding the use of antibiotics to manage acute uncomplicated diverticulitis in hospitalized patients, with controversial information about it. Methods A search was done in Epistemonikos, the most comprehensive health-related systematic review database, maintained by screening multiple information sources including MEDLINE/PubMed, EMBASE, Cochrane, among others. Data were extracted from the identified systematic reviews, data from primary studies were analyzed, which in this work considered only randomized clinical trials, a meta-analysis was done, and a summary table of results was created using GRADE methodology. Results and conclusions Eleven systematic reviews were identified that included seven primary studies in total, of which two were randomized control trials. We concluded that the use of antibiotics in acute uncomplicated diverticulitis could slightly increase complications and result in a minor or no difference in the risk of recurrence and need for urgent surgery. However, the certainty of the evidence is low. Regarding hospital stay and readmission, it was not possible to evaluate the effect due to a low certainty of evidence.

Sign in / Sign up

Export Citation Format

Share Document