scholarly journals Microsomal triglyceride transfer protein inhibitor lomitapide-induced liver toxicity is ameliorated by Triiodothyronine treatment following improved bile homeostasis and β-oxidation

2021 ◽  
pp. 115825
Author(s):  
Vishal Patel ◽  
Amit Joharapurkar ◽  
Samadhan Kshirsagar ◽  
Maulik Patel ◽  
Hiren Patel ◽  
...  
Keyword(s):  
Liver Toxicity ◽  
Microsomal Triglyceride Transfer Protein ◽  
Protein Inhibitor ◽  
Transfer Protein

The Effects of a Microsomal Triglyceride Transfer Protein Inhibitor on Fat Soluble Compounds

2007 ◽  
Vol 107 (8) ◽  
pp. A31
Author(s):  
L.T. Bloedon ◽  
M. Cuchel ◽  
T. Santoroski ◽  
W. Sasiela ◽  
D.J. Rader
Keyword(s):  
Microsomal Triglyceride Transfer Protein ◽  
Protein Inhibitor ◽  
Transfer Protein

scholarly journals Crystal structure of 9-(4-bromobutyl)-9H-fluorene-9-carboxylic acid

2014 ◽  
Vol 70 (10) ◽  
pp. o1118-o1119
Author(s):  
Xu-Yang Zhang ◽  
Bing-Ni Liu ◽  
Ping-Bao Wang ◽  
Deng-Ke Liu
Keyword(s):  
Microsomal Triglyceride Transfer Protein ◽  
Dihedral Angles ◽  
Asymmetric Unit ◽  
Protein Inhibitor ◽  
Transfer Protein ◽  
Compound C ◽  
Carboxylate Groups ◽  
The Mean ◽  
Independent Molecules ◽  
Centrosymmetric Dimers

The title compound, C18H17BrO2, is a key intermediate in the synthesis of lomitapide mesylate, a microsomal triglyceride transfer protein inhibitor. Its asymmetric unit contains two independent molecules with slightly different conformations; the mean planes of the 4-bromobutyl and carboxylate groups in the two molecules form dihedral angles of 24.54 (12) and 17.10 (18)°. In the crystal, carboxylate groups are involved in O—H...O hydrogen bonding, which leads to the formation of two crystallographically independent centrosymmetric dimers. Weak intermolecular C—H...O interactions further link these dimers into layers parallel to thebcplane.

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