Background:
Paracetamol is a common antipyretic and analgesic drug, but its excessive
intake can accumulate toxic metabolites and cause kidney and liver damage, so it is critical to determine
the content of paracetamol for clinical diagnosis and dose use.
Methods:
Au-reduced graphene oxide (Au-rGO) nanocomposite decorated with poly(L-cysteine) on
carbon paste electrode was fabricated for the determination of paracetamol. Au-rGO was first coelectrodeposited
on the carbon paste electrode surface. Afterwards, L-cysteine was electropolymerized
to fabricate the Au-rGO/poly(L-cysteine) modified carbon paste electrode. Scanning electron
microscope was used to characterize the morphology of Au-rGO and poly(L-cysteine)/Au-rGO. The
electrochemical properties of the sensor were studied by cyclic voltammetry and differential pulse
voltammetry.
Results:
After exploring the optimal conditions, the sensor showed a wide linear response for paracetamol
detection in the range of 1-200 μM with a detection limit of 0.5 μM (S/N = 3).
Conclusion:
The fabricated sensor demonstrated good sensitivity with rapid detection capacity in real
samples.