Diversity oriented catalyst-free and solvent-free one-pot MCR at room temperature: rapid and regioselective convergent approach to highly functionalized dihydro-4H-thiopyrans
Visible light mediated, an eco-friendlier synthetic protocol for dihydropyrano[2,3-c]pyrazoles via catalyst-free and solvent-free conditions at room temperature.
A rapid and efficient solvent-free one-pot synthesis of novel alkyl amino aryl furan tricarbonitrile derivatives is described under catalyst-free conditions.
A combinatorial library of benzylpyrazolyl coumarin derivatives have been synthesized by a green one-pot four-component reaction between aryl hydrazine/hydrazine hydrate (1), ethyl acetoacetate (2), aromatic aldehydes (3) and 4-hydroxycoumarin (4) catalyzed by niobium pentachloride with silver salt under solvent-free conditions has been developed. Experimental simplicity, simple work-up procedure and solvent-free reaction condition at room temperature are important features of the present protocol.
The development of a silica-promoted highly selective synthesis of 1,2 or 1,3-dithioethers via solvent-free one-pot tandem reactions of an allyl bromide with excess thiol at room temperature is described. The choice of silica gel, either pre-calcined or moistened with water, exhibited notable regioselectivity in the formation of dithioethers. Plausible mechanistic routes were explored and postulated.
Efficient One-Pot Synthesis of Diphenyl-2,4-dioxa-8,10-diazaspiro-[5.5]undecane-1,5,9-trione Derivatives under Solvent-Free and Catalyst-Free
