Expected and Observed Glomerular Filtration Rates in Kidney Transplant Patients Converted to Once Daily Tacrolimus: 10 Years of Follow-up

2020 ◽  
Vol 52 (5) ◽  
pp. 1547-1551
Author(s):  
Francesca Tinti ◽  
Gabriele Schiaffini ◽  
Ilaria Umbro ◽  
Assunta Zavatto ◽  
Luca Poli ◽  
...  
Keyword(s):  
Glomerular Filtration ◽  
Kidney Transplant ◽  
Once Daily ◽  
Transplant Patients ◽  
Kidney Transplant Patients

scholarly journals Effects of Late Conversion from Twice-Daily to Once-Daily Slow Release Tacrolimus on the Insulin Resistance Indexes in Kidney Transplant Patients

2021 ◽  
Vol 2 (1) ◽  
pp. 49-56
Author(s):  
Valeria Cademartori ◽  
Fabio Massarino ◽  
Emanuele L. Parodi ◽  
Ernesto Paoletti ◽  
Rodolfo Russo ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Kidney Transplant ◽  
Slow Release ◽  
Density Lipoprotein ◽  
Blood Levels ◽  
Transplant Recipients ◽  
Once Daily ◽  
C Peptide ◽  
Transplant Patients ◽  
Kidney Transplant Patients

The use of tacrolimus (Tac) may be involved in the development of new-onset diabetes after transplantation (NODAT) in a dose-related manner. This study aimed to evaluate the effects of a standard twice-daily formulation of Tac (TacBID) vs. the once-daily slow-release formulation (TacOD) on the basal insulin resistance indexes (Homa and McAuley), and related metabolic parameters, in a cohort of kidney transplant patients. We retrospectively evaluated 20 stable renal transplant recipients who were switched from TacBID to TacOD. Blood levels of Tac were analyzed at one-month intervals from 6 months before to 8 months after conversion. Moreover, Homa and McAuley indexes, C-peptide, insulin, HbA1c, uric acid, triglycerides, low-density lipoprotein (LDL) and high-density lipoprotein (HDL)-cholesterol serum levels and their associations with Tac levels were evaluated. We observed a significant decrease in Tac exposure (8.5 ± 2 ng/mL, CV 0.23 vs. 6.1 ± 1.9 ng/mL, CV 0.31, TacBID vs. TacOD periods, p < 0.001) and no significant changes in Homa (1.42 ± 0.4 vs. 1.8 ± 0.7, p > 0.05) and McAuley indexes (7.12 ± 1 vs. 7.58 ± 1.4, p > 0.05). Similarly, blood levels of glucose, insulin, HbA1c, lipids, and uric acid were unchanged between the two periods, while C-peptide resulted significantly lower after conversion to TacOD. These data suggest that in kidney transplant recipients, reduced Tac exposure has no significant effects on basal insulin sensitivity indexes and metabolic parameters.

scholarly journals Beneficial Effect of Conversion to Belatacept in Kidney-Transplant Patients with a Low Glomerular-Filtration Rate

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Julie Belliere ◽  
Céline Guilbeau-Frugier ◽  
Arnaud Del Bello ◽  
Laure Esposito ◽  
Caroline Capuani ◽  
...  
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Kidney Transplant ◽  
Kidney Function ◽  
Filtration Rate ◽  
Case Reports ◽  
Rescue Therapy ◽  
Mtor Inhibitors ◽  
Transplant Patients ◽  
Kidney Transplant Patients

Belatacept has been found to be efficient at preserving good kidney function in maintenance kidney-transplant patients. Herein, we report on the use of belatacept as a rescue therapy for two kidney-transplant patients presenting with severe adverse events after treatment with calcineurin inhibitors (CNIs) and mammalian target-of-rapamycin (mTOR) inhibitors. Two kidney-transplant patients developed severely impaired kidney function after receiving CNIs. The use of everolimus was associated with severe angioedema. Belatacept was then successfully used to improve kidney function in both cases, even though estimated glomerular-filtration rate before conversion was <20 mL/min. These case reports show that belatacept can be used as a rescue therapy, even if kidney function is very low in kidney-transplant patients who cannot tolerate CNIs and/or mTOR inhibitors.

Improvement of Graft Function after Conversion to Once Daily Tacrolimus of Stable Kidney Transplant Patients

2010 ◽  
Vol 42 (10) ◽  
pp. 4047-4048 ◽  
Author(s):  
F. Tinti ◽  
A. Meçule ◽  
L. Poli ◽  
A. Bachetoni ◽  
I. Umbro ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Graft Function ◽  
Once Daily ◽  
Transplant Patients ◽  
Kidney Transplant Patients

LONG-TERM FOLLOW-UP OF SIROLIMUS (SLR) MONOTHERAPY IN KIDNEY TRANSPLANT PATIENTS

2008 ◽  
Vol 86 (Supplement) ◽  
pp. 535
Author(s):  
R Pinto ◽  
M Arellano ◽  
A Franco ◽  
J C. Ruiz ◽  
Y Armendariz ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Transplant Patients ◽  
Long Term Follow Up ◽  
Kidney Transplant Patients
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