Immunoglobulin isotype switching of antibodies to vimentin is associated with development of transplant glomerulopathy following human renal transplantation

2017 ◽  
Vol 45 ◽  
pp. 42-47 ◽  
Author(s):  
Muthukumar Gunasekaran ◽  
Thin Thin Maw ◽  
Rowena Delos Santos ◽  
Surendra Shenoy ◽  
Jason Wellen ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Isotype Switching ◽  
Immunoglobulin Isotype ◽  
Transplant Glomerulopathy

CYTOMEGALOVIRUS INFECTION COMPLICATING RENAL TRANSPLANTATION AND ITS RELATIONSHIP TO ACUTE TRANSPLANT GLOMERULOPATHY

1988 ◽  
Vol 45 (4) ◽  
pp. 706-709 ◽  
Author(s):  
Neil W. Boyee ◽  
Kathy Hayes ◽  
David Gee ◽  
Stephen R. Holdsworth ◽  
Napier M. Thomson ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Cytomegalovirus Infection ◽  
Transplant Glomerulopathy

scholarly journals Comparative Analysis of Antibody Responses against HSP60, Invariant Surface Glycoprotein 70, and Variant Surface Glycoprotein Reveals a Complex Antigen-Specific Pattern of Immunoglobulin Isotype Switching during Infection byTrypanosoma brucei

2000 ◽  
Vol 68 (2) ◽  
pp. 848-860 ◽  
Author(s):  
Magdalena Radwanska ◽  
Stefan Magez ◽  
Alain Michel ◽  
Benoît Stijlemans ◽  
Maurice Geuskens ◽  
...  
Keyword(s):  
Comparative Analysis ◽  
T Cell ◽  
Antibody Responses ◽  
Surface Glycoprotein ◽  
Variant Surface Glycoprotein ◽  
Mammalian Host ◽  
Immune Recognition ◽  
Isotype Switching ◽  
Invariant Surface ◽  
Immunoglobulin Isotype

ABSTRACT During Trypanosoma brucei infections, the response against the variant surface glycoprotein (VSG) of the parasite represents a major interaction between the mammalian host immune system and the parasite surface. Since immune recognition of other parasite derived factors also occurs, we examined the humoral host response against trypanosome heat shock protein 60 (HSP60), a conserved antigen with an autoimmune character. During experimental T. bruceiinfection in BALB/c mice, the anti-HSP60 response was induced when parasites differentiated into stumpy forms. This response was characterized by a stage-specific immunoglobulin isotype switching as well as by the induction of an autoimmune response. Specific recognition of trypanosome HSP60 was found to occur during the entire course of infection. Immunoglobulin G2a (IgG2a) and IgG2b antibodies, induced mainly in a T-cell-independent manner, were observed during the first peak of parasitemia, whereas IgG1 and IgG3 antibodies were found at the end of the infection, due to a specific T-cell-mediated response. Comparative analysis of the kinetics of anti-HSP60, anti-invariant surface glycoprotein 70 (ISG70), and anti-VSG antibody responses indicated that the three trypanosome antigens give rise to specific and independent patterns of immunoglobulin isotype switching.

Human Immunoglobulin Isotype Switching

2008 ◽  
Vol 764 (1) ◽  
pp. 136-147
Author(s):  
E. E. MAX ◽  
F. C. MILLS ◽  
N. HARINDRANATH
Keyword(s):  
Human Immunoglobulin ◽  
Isotype Switching ◽  
Immunoglobulin Isotype

Early occurrence of immunoglobulin isotype switching in human fetal liver

1991 ◽  
Vol 28 (7) ◽  
pp. 753-761 ◽  
Author(s):  
Michèle Milili ◽  
Michel Fougereau ◽  
Paul Guglielmi ◽  
Claudine schiff
Keyword(s):  
Fetal Liver ◽  
Isotype Switching ◽  
Immunoglobulin Isotype ◽  
Human Fetal Liver ◽  
Early Occurrence
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