A conserved 37 kDa outer membrane protein of Edwardsiella tarda is an effective vaccine candidate

Vaccine ◽  
2004 ◽  
Vol 22 (25-26) ◽  
pp. 3411-3418 ◽  
Author(s):  
Kenji Kawai ◽  
Ying Liu ◽  
Kouhei Ohnishi ◽  
Syun-ichirou Oshima
Keyword(s):  
Membrane Protein ◽  
Outer Membrane ◽  
Outer Membrane Protein ◽  
Vaccine Candidate ◽  
Edwardsiella Tarda ◽  
Effective Vaccine

A conserved outer membrane protein as an effective vaccine candidate from Vibrio alginolyticus

Aquaculture ◽  
2008 ◽  
Vol 278 (1-4) ◽  
pp. 5-9 ◽  
Author(s):  
Rong-Hua Qian ◽  
Zhao-Hua Xiao ◽  
Chong-Wen Zhang ◽  
Wu-Ying Chu ◽  
Lian-Sheng Wang ◽  
...  
Keyword(s):  
Membrane Protein ◽  
Outer Membrane ◽  
Outer Membrane Protein ◽  
Vaccine Candidate ◽  
Vibrio Alginolyticus ◽  
Effective Vaccine

scholarly journals Antigenic Structure of Outer Membrane Protein E ofMoraxella catarrhalis and Construction and Characterization of Mutants

2000 ◽  
Vol 68 (11) ◽  
pp. 6250-6256 ◽  
Author(s):  
Timothy F. Murphy ◽  
Aimee L. Brauer ◽  
Norine Yuskiw ◽  
Thomas J. Hiltke
Keyword(s):  
Monoclonal Antibodies ◽  
Membrane Protein ◽  
Outer Membrane ◽  
Outer Membrane Protein ◽  
Vaccine Antigen ◽  
Antigenic Structure ◽  
Effective Vaccine ◽  
Fusion Peptides ◽  
Bacterial Surface ◽  
Normal Human

ABSTRACT Outer membrane protein E (OMP E) is a 50-kDa protein ofMoraxella catarrhalis which possesses several characteristics indicating that the protein will be an effective vaccine antigen. To study the antigenic structure of OMP E, eight monoclonal antibodies were developed and characterized. Three of the antibodies recognized epitopes which are present on the bacterial surface. Fusion peptides corresponding to overlapping regions of OMP E were constructed, and immunoblot assays were performed to localize the areas of the molecule bound by the monoclonal antibodies. These studies identified a surface-exposed epitope in the region of amino acids 80 through 180. To further study the protein, two mutants which lack OMP E were constructed. In bactericidal assays, the mutants were more readily killed by normal human serum compared to the isogenic parent strains. These results indicate that OMP E is involved in the expression of serum resistance of M. catarrhalis.

The outer membrane protein, LamB (maltoporin), is a versatile vaccine candidate among the Vibrio species

Vaccine ◽  
2014 ◽  
Vol 32 (7) ◽  
pp. 809-815 ◽  
Author(s):  
Jingsheng Lun ◽  
Changyan Xia ◽  
Chuanfei Yuan ◽  
Yueling Zhang ◽  
Mingqi Zhong ◽  
...  
Keyword(s):  
Membrane Protein ◽  
Outer Membrane ◽  
Outer Membrane Protein ◽  
Vaccine Candidate ◽  
Vibrio Species
Sign in / Sign up

Export Citation Format

Share Document