Cytocentering patch clamp recordings of iPSC-derived cardiomyocytes and of HEK cells expressing cardiac ion channels at physiological temperature

2015 ◽  
Vol 75 ◽  
pp. 165-166
Author(s):  
Dirck Lassen ◽  
Stefanie Frech ◽  
Bogdan Amuzescu ◽  
Olaf Scheel ◽  
Thomas Knott
Keyword(s):  
Ion Channels ◽  
Patch Clamp ◽  
Physiological Temperature ◽  
Cardiac Ion Channels ◽  
Hek Cells

Safety pharmacology assessment of cardiac ion channels by manual patch clamp with CiPA protocols

2020 ◽  
Vol 105 ◽  
pp. 106733
Author(s):  
Hiroshi Matsukawa ◽  
Taku Izumi ◽  
Mao Yamaguchi ◽  
Satomi Tomizawa ◽  
Hironori Ohshiro
Keyword(s):  
Ion Channels ◽  
Patch Clamp ◽  
Safety Pharmacology ◽  
Cardiac Ion Channels

scholarly journals Validation of an Automated Patch-Clamp Screening Assay on Human Kir2.1 Cardiac Ion Channels

2018 ◽  
Vol 114 (3) ◽  
pp. 311a
Author(s):  
Georg Andrees Bohme ◽  
Camille Sanson ◽  
Brigitte Schombert ◽  
Michel Partiseti
Keyword(s):  
Ion Channels ◽  
Patch Clamp ◽  
Screening Assay ◽  
Cardiac Ion Channels ◽  
Automated Patch Clamp

scholarly journals Synthesis and Evaluation of Novel α-Aminoamides Containing Benzoheterocyclic Moiety for the Treatment of Pain

Molecules ◽  
2021 ◽  
Vol 26 (6) ◽  
pp. 1716
Author(s):  
Kun Tong ◽  
Ruotian Zhang ◽  
Fengzhi Ren ◽  
Tao Zhang ◽  
Junlin He ◽  
...  
Keyword(s):  
Ion Channels ◽  
Patch Clamp ◽  
Formalin Test ◽  
Sodium Ion ◽  
Inhibitory Potency ◽  
Voltage Gated ◽  
Patch Clamp Electrophysiology ◽  
Sodium Ion Channels

Novel α-aminoamide derivatives containing different benzoheterocyclics moiety were synthesized and evaluated as voltage-gated sodium ion channels blocks the treatment of pain. Compounds 6a, 6e, and 6f containing the benzofuran group displayed more potent in vivo analgesic activity than ralfinamide in both the formalin test and the writhing assay. Interestingly, they also exhibited potent in vitro anti-Nav1.7 and anti-Nav1.8 activity in the patch-clamp electrophysiology assay. Therefore, compounds 6a, 6e, and 6f, which have inhibitory potency for two pain-related Nav targets, could serve as new leads for the development of analgesic medicines.

Is manual patch clamp still the gold standard assay for ion channels?

2016 ◽  
Vol 81 ◽  
pp. 339
Author(s):  
Elisa Ballini ◽  
Corrado Carignani ◽  
Ezio Bettini ◽  
Maria Pilla
Keyword(s):  
Ion Channels ◽  
Patch Clamp ◽  
Gold Standard ◽  
Standard Assay

scholarly journals Species- and tissue-dependent effects of NO and cyclic GMP on cardiac ion channels

2005 ◽  
Vol 142 (2) ◽  
pp. 136-143 ◽  
Author(s):  
Rodolphe Fischmeister ◽  
Liliana Castro ◽  
Aniella Abi-Gerges ◽  
Francesca Rochais ◽  
Grégoire Vandecasteele
Keyword(s):  
Ion Channels ◽  
Cyclic Gmp ◽  
Cardiac Ion Channels

Regulatory effects of non-steroidal anti-inflammatory drugs on cardiac ion channels Nav1.5 and Kv11.1

2021 ◽  
Vol 338 ◽  
pp. 109425
Author(s):  
Yijia Xu ◽  
Wenwen Li ◽  
Yunuo Han ◽  
Hongyu Liu ◽  
Suli Zhang ◽  
...  
Keyword(s):  
Ion Channels ◽  
Cardiac Ion Channels ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Regulatory Effects
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