scholarly journals Predicting Solubility/Miscibility in Amorphous Dispersions: It Is Time to Move Beyond Regular Solution Theories

2018 ◽  
Vol 107 (1) ◽  
pp. 24-33 ◽  
Author(s):  
Bradley D. Anderson
Keyword(s):  
Regular Solution ◽  
Amorphous Dispersions

scholarly journals Clozapine-carboxylic acid plasticized co-amorphous dispersions: Preparation, characterization and solution stability evaluation

2015 ◽  
Vol 65 (2) ◽  
pp. 133-146 ◽  
Author(s):  
Ahmed Mahmoud Abdelhaleem Ali ◽  
Adel Ahmed Ali ◽  
Ibrahim Abdullah Maghrabi
Keyword(s):  
Carboxylic Acid ◽  
Tartaric Acid ◽  
Molar Ratio ◽  
Sublingual Administration ◽  
Solution Stability ◽  
X Ray Diffraction ◽  
Scanning Calorimetry ◽  
Great Chance ◽  
Amorphous Dispersions ◽  
Pass Metabolism

Abstract This study addressed the possibility of forming of co-amorphous systems between clozapine (CZ) and various carboxylic acid plasticizers (CAPs). The aim was to improve the solubility and oral bioavailability of clozapine. Co-amorphous dispersions were prepared using modified solvent evaporation methodology at drug/plasticizer stoichiometric ratios of 1:1, 1:1.5 and 1:2. Solid state characterization was performed using differential scanning calorimetry, X-ray diffraction and infra red spectroscopy. Highly soluble homogeneous co-amorphous dispersions were formed between clozapine and CAPs via hydrogen bonding. The co-amorphous dispersions formed with tartaric acid (1:2) showed the highest dissolution percentage (> 95 % in 20 minutes) compared to pure crystalline CZ (56 %). Highly stable solutions were obtained from co-amorphous CZ-citric and CZ-tartaric acid at 1:1.5 molar ratio. The prepared dispersions suggest the possibility of peroral or sublingual administration of highly soluble clozapine at a reduced dose with the great chance to bypass the first pass metabolism.

Grain Boundary Solute Drag Model in Regular Solution Alloys

2021 ◽  
Vol 127 (17) ◽  
Author(s):  
Malek Alkayyali ◽  
Fadi Abdeljawad
Keyword(s):  
Grain Boundary ◽  
Regular Solution ◽  
Solute Drag ◽  
Drag Model
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