scholarly journals Loss of primary cilia affect neural crest cell behavior and leads to craniofacial defects

2010 ◽  
Vol 344 (1) ◽  
pp. 467
Author(s):  
Samantha Brugmann ◽  
Nancy C. Allen ◽  
Aaron W. James ◽  
Zesemayat Mekonnen ◽  
Elena Madan ◽  
...  
Keyword(s):  
Neural Crest ◽  
Primary Cilia ◽  
Neural Crest Cell ◽  
Cell Behavior ◽  
Craniofacial Defects ◽  
Crest Cell

Neural crest cell-specific inactivation ofNipblorMau2during mouse development results in a late onset of craniofacial defects

genesis ◽  
2014 ◽  
Vol 52 (7) ◽  
pp. 687-694 ◽  
Author(s):  
Terence Gordon Smith ◽  
Steve Laval ◽  
Fangli Chen ◽  
Matthew James Rock ◽  
Tom Strachan ◽  
...  
Keyword(s):  
Neural Crest ◽  
Late Onset ◽  
Neural Crest Cell ◽  
Mouse Development ◽  
Craniofacial Defects ◽  
Crest Cell

scholarly journals The “Domestication Syndrome” in Mammals: A Unified Explanation Based on Neural Crest Cell Behavior and Genetics

Genetics ◽  
2014 ◽  
Vol 197 (3) ◽  
pp. 795-808 ◽  
Author(s):  
Adam S. Wilkins ◽  
Richard W. Wrangham ◽  
W. Tecumseh Fitch
Keyword(s):  
Neural Crest ◽  
Neural Crest Cell ◽  
Cell Behavior ◽  
Domestication Syndrome ◽  
Crest Cell

scholarly journals Control of neural crest cell behavior and migration

2010 ◽  
Vol 4 (4) ◽  
pp. 586-594 ◽  
Author(s):  
Matthew R. Clay ◽  
Mary C. Halloran
Keyword(s):  
Neural Crest ◽  
Neural Crest Cell ◽  
Cell Behavior ◽  
And Migration ◽  
Crest Cell

scholarly journals Ablation of Ezh2 in neural crest cells leads to Hirschsprung's disease-like phenotype in mice

2018 ◽  
Author(s):  
Hana Kim ◽  
Ingeborg M. Langohr ◽  
Mohammad Faisal ◽  
Margaret McNulty ◽  
Caitlin Thorn ◽  
...  
Keyword(s):  
Neural Crest ◽  
Ganglion Cells ◽  
Neural Crest Cell ◽  
Cell Development ◽  
Rt Pcr ◽  
Promoter Regions ◽  
Epigenetic Modifier ◽  
Craniofacial Defects ◽  
Crest Cell

AbstractIn the current study, we examined the role of Ezh2 as an epigenetic modifier for the enteric neural crest cell development through H3K27me3. Ezh2 conditional null mice were viable up to birth, but died within the first hour of life. In addition to craniofacial defects, Ezh2 conditional null mice displayed reduced number of ganglion cells in the enteric nervous system. RT-PCR and ChIP assays indicated aberrant up-regulation of Zic1, Pax3, and Sox10 and loss of H3K27me3 marks in the promoter regions of these genes in the myenteric plexus. Overall, these results suggest that Ezh2 is an important epigenetic modifier for the enteric neural crest cell development through repression of Zic1, Pax3, and Sox10.

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