Accuracy of frozen section diagnosis of borderline ovarian tumors

2011 ◽  
Vol 122 (1) ◽  
pp. 127-131 ◽  
Author(s):  
Taejong Song ◽  
Chel Hun Choi ◽  
Ha-Jeong Kim ◽  
Min Kyu Kim ◽  
Tae-Joong Kim ◽  
...  
Keyword(s):  
Frozen Section ◽  
Ovarian Tumors ◽  
Borderline Ovarian Tumors ◽  
Frozen Section Diagnosis

Accuracy of frozen section diagnosis in ovarian tumors: Is there a change in the course of time?

2003 ◽  
Vol 13 (5) ◽  
pp. 593-597 ◽  
Author(s):  
M. Gol ◽  
A. Baloglu ◽  
S. Yigit ◽  
M. Dogan ◽  
Ç. Aydin ◽  
...  
Keyword(s):  
Frozen Section ◽  
Correct Diagnosis ◽  
False Negative ◽  
Ovarian Tumors ◽  
Borderline Ovarian Tumors ◽  
Frozen Section Examination ◽  
Benign Ovarian Tumor ◽  
Frozen Section Diagnosis ◽  
Accuracy Rates ◽  
Higher Sensitivity

A retrospective study of 222 ovarian biopsy results between January 1, 2000 and August 31, 2002 was examined to determine the accuracy of frozen section diagnosis. In addition we reviewed all previous studies that examined the accuracy rates of frozen section diagnosis in ovarian tumors. Histopathologic examination results of frozen section biopsies were concordant with paraffin diagnosis in 92% of all cases. The sensitivity rates for benign, malignant, and borderline ovarian tumors were 98%, 88.7%, and 61%, respectively. There were five (2.2%) false-positive (overdiagnosed), and 13 (5.4%) false-negative (underdiagnosed) patients in frozen section examination. Frozen section examination of mucinous tumors showed higher underdiagnosis rates (20%). Review of previous studies showed no significant variation in accuracy rates of frozen section diagnosis for benign and malignant ovarian tumors, in relation with time. We found low accuracy rates for borderline ovarian tumors which was similar with the previous studies. Hovewer, there were consistent and relatively higher sensitivity rates for borderline ovarian tumors in the recent studies. As a result, we conclude that frozen section evaluation in identifying a malignant or benign ovarian tumor is accurate enough for the correct diagnosis. Since accuracy rates for borderline ovarian tumors are low, we should have more improvement in the correct diagnosis.

scholarly journals Accuracy of Intraoperative Frozen Section Diagnosis of Borderline Ovarian Tumors by Hospital Type

2019 ◽  
Vol 26 (1) ◽  
pp. 87-93 ◽  
Author(s):  
Jaimin S. Shah ◽  
Michael Mackelvie ◽  
David M. Gershenson ◽  
Preetha Ramalingam ◽  
Marylee M. Kott ◽  
...  
Keyword(s):  
Frozen Section ◽  
Ovarian Tumors ◽  
Hospital Type ◽  
Intraoperative Frozen Section ◽  
Borderline Ovarian Tumors ◽  
Frozen Section Diagnosis

Does Intraoperative Frozen Section Diagnosis Correlate with Final Pathology in Borderline Ovarian Tumors

2017 ◽  
Vol 147 (1) ◽  
pp. 217-218
Author(s):  
J. Shah ◽  
M. Mackelvie ◽  
P. Ramalingam ◽  
P. Gauthier ◽  
M. Kott ◽  
...  
Keyword(s):  
Frozen Section ◽  
Ovarian Tumors ◽  
Final Pathology ◽  
Intraoperative Frozen Section ◽  
Borderline Ovarian Tumors ◽  
Frozen Section Diagnosis

scholarly journals The value of frozen section evaluation in the management of borderline ovarian tumors

2011 ◽  
Vol 7 (4) ◽  
pp. 416 ◽  
Author(s):  
Emre Gultekin ◽  
Basak Cingillioglu ◽  
Muzaffer Sanci ◽  
OzgeElmastas Gultekin ◽  
Sevil Sayhan ◽  
...  
Keyword(s):  
Frozen Section ◽  
Ovarian Tumors ◽  
Borderline Ovarian Tumors ◽  
Section Evaluation

Frozen section in borderline ovarian tumors: is it reliable?

2014 ◽  
Vol 181 ◽  
pp. 115-118 ◽  
Author(s):  
Isin Ureyen ◽  
Taner Turan ◽  
Derya Akdag Cirik ◽  
Tolga Tasci ◽  
Nurettin Boran ◽  
...  
Keyword(s):  
Frozen Section ◽  
Ovarian Tumors ◽  
Borderline Ovarian Tumors

scholarly journals OP03.07: Borderline ovarian tumors and frozen section: role of preoperative He4 and ROMA score to increase frozen section accuracy

2015 ◽  
Vol 46 ◽  
pp. 61-61
Author(s):  
S. Gizzo ◽  
M. Noventa ◽  
A. Vitagliano ◽  
M. Quaranta ◽  
R. Venturella ◽  
...  
Keyword(s):  
Frozen Section ◽  
Ovarian Tumors ◽  
Borderline Ovarian Tumors

Diagnostic Discordance in Intraoperative Frozen Section Diagnosis of Ovarian Tumors: A Literature Review and Analysis of 871 Cases Treated at a Japanese Cancer Center

2020 ◽  
pp. 106689692096051
Author(s):  
Hiroshi Yoshida ◽  
Hiroki Tanaka ◽  
Takafumi Tsukada ◽  
Naoko Abeto ◽  
Mayumi Kobayashi-Kato ◽  
...  
Keyword(s):  
Literature Review ◽  
Frozen Section ◽  
Malignant Potential ◽  
Ovarian Tumors ◽  
Serous Carcinoma ◽  
Low Grade ◽  
Borderline Tumor ◽  
Mucinous Tumor ◽  
Ovarian Metastases ◽  
Frozen Section Diagnosis

Background This study examined the accuracy and pitfalls associated with frozen section diagnosis of primary ovarian tumors and ovarian metastases based on the 2014 World Health Organization classification (WHO) criteria and proposed improvements from a pathologist’s perspective. Methods We microscopically reviewed 871 cases of primary ovarian tumor (N = 802) and ovarian metastasis (N = 69) and compared the results of frozen sections with the final diagnosis. Malignant potential concordance (benign, borderline, or malignant) and specific discordant diagnosis rates were analyzed. Finally, we conducted a unique literature review of specific diagnostic errors in the frozen section diagnosis of primary ovarian tumors. Results Of 802 primary ovarian tumors, 50 (6.2%) cases showed discordant diagnoses in which mucinous carcinoma (40.5%), low-grade serous carcinoma (LGSC; 31.3%), and mucinous borderline tumor (18.4%) were frequently misinterpreted. Of 69 ovarian metastases, all 4 cases of low-grade appendiceal mucinous neoplasm (LAMN) were misdiagnosed as primary ovarian mucinous tumor. A literature review revealed that mucinous/serous borderline tumor or carcinoma accounted for approximately 70% of 217 reported discordant diagnoses. Conclusion In the present study, the concordance rate of malignant potential of the tumor was comparable to that previously reported. Even in the 2014 WHO classification, primary ovarian mucinous borderline tumor/carcinoma and LGSC still comprised the majority of discordant cases. Grossing methods that reduce sampling error are required. LAMN was frequently misinterpreted as a benign or borderline ovarian mucinous tumor. To prevent this error, a differential algorithm integrating clinical information and gross findings should be developed.

scholarly journals Borderline Ovarian Tumors and Diagnostic Dilemma of Intraoperative Diagnosis: Could Preoperative He4 Assay and ROMA Score Assessment Increase the Frozen Section Accuracy? A Multicenter Case-Control Study

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Salvatore Gizzo ◽  
Roberto Berretta ◽  
Stefania Di Gangi ◽  
Maria Guido ◽  
Giuliano Carlo Zanni ◽  
...  
Keyword(s):  
Frozen Section ◽  
Menopausal Status ◽  
Laparoscopic Approach ◽  
Preoperative Assessment ◽  
Figo Stage ◽  
Serum Markers ◽  
Ovarian Tumors ◽  
Diagnostic Dilemma ◽  
Additional Information ◽  
Borderline Ovarian Tumors

The aim of our study was to assess the value of a preoperative He4-serum-assay and ROMA-score assessment in improving the accuracy of frozen section histology in the diagnosis of borderline ovarian tumors (BOT). 113 women presenting with a unilateral ovarian mass diagnosed as serous/mucinous BOT at frozen-section-histology (FS) and/or confirmed on final pathology were recruited. Pathologists were informed of the results of preoperative clinical/instrumental assessment of all patients. For Group_A patients, additional information regarding He4, CA125, and ROMA score was available (in Group_B only CA125 was known). The comparison between Group A and Group B in terms of FS accuracy, demonstrated a consensual diagnosis in 62.8% versus 58.6% (P: n.s.), underdiagnosis in 25.6% versus 41.4% (P<0.05), and overdiagnosis in 11.6% versus 0% (P<0.01). Low FS diagnostic accuracy was associated with menopausal status (OR: 2.13), laparoscopic approach (OR: 2.18), mucinous histotype (OR: 2.23), low grading (OR: 1.30), and FIGO stage I (OR: 2.53). Ultrasound detection of papillae (OR: 0.29), septa (OR: 0.39), atypical vascularization (OR: 0.34), serum He4 assay (OR: 0.39), and ROMA score assessment (OR: 0.44) decreased the probability of underdiagnosis. A combined preoperative assessment through serum markers and ultrasonographic features may potentially reduce the risk of underdiagnosis of BOTs on FS while likely increasing the concomitant incidence of false-positive events.

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