Abstract
Study question
To assess the role of subcutaneous granulocyte colony-stimulating factor (G-CSF) in thin endometrium cases.
Summary answer
G CSF has beneficial role to improve the endometrium thickness in thin endometrium.
What is known already
Endometrium is very important for embryo implantation and the endometrial thickness is the marker of receptivity of the endometrium.
Study design, size, duration
Study design - Retrospective analysis
Size - 88 infertile females with thin endometrium (< 7 mm) in the age group of 23 to 40 years Duration - one year.
Participants/materials, setting, methods
In the group 1 of 44 females, subcutaneous infusion of G CSF (300 mcg/ml) was added along with other supplements and if lining was not more than 7 mm in 72 hours, then second infusion was given. In the group 2 of 44 females, only estradiol valerate and sildenafil were given.The efficacy of G CSF was evaluated by assessing the endometrium thickness before embryo transfer, pregnancy rates and clinical pregnancy rates.
Main results and the role of chance
There was no difference between the two groups regarding demographic variables, egg reserve, sperm parameters, number of embryos transferred and embryo quality. . The pregnancy rate was 60% (24 out of 40 cases) in the group 1 that was significantly higher than in-group 2 that was 31% (9 out of 29 cases) with p value < 0.0001. The clinical pregnancy rate was also significantly higher in-group 1 (55%) as compared to group 2 (24%) with p value < 0.0001.
Limitations, reasons for caution
Further larger cohort studies are required to explore the subcutaneous role of G CSF in thin endometrium.
Wider implications of the findings: Granulocyte colony-stimulating factor has beneficial role to improve the endometrium thickness in thin endometrium. In most of previous studies, the intrauterine infusion of G CSF was given to improve the uterine lining. This is one of the few studies done that showed subcutaneous role of G CSF in thin endometrium.
Trial registration number
Not applicable
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