Cardioprotective effects of acute and chronic treatment with flavonoid quercetin against ischemia/reperfusion injury in isolated rat hearts: focus on the role of age in the efficiency of treatment

2018 ◽  
Vol 120 ◽  
pp. 20-21 ◽  
Author(s):  
M. Bartekova ◽  
K. Ferenczyova ◽  
J. Radosinska ◽  
D. Pancza ◽  
M. Barancik ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Chronic Treatment ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Rat Hearts ◽  
Acute And Chronic Treatment ◽  
Flavonoid Quercetin ◽  
Cardioprotective Effects ◽  
Isolated Rat

scholarly journals Hydrogen sulfide-mediated cardioprotection against ischemia reperfusion is linked to KATP channel for mitochondrial preservation but not for its distinct preference on interfibrillar mitochondria

2019 ◽  
Vol 14 (2) ◽  
pp. 107-115 ◽  
Author(s):  
Priyadharshini Chandrasekaran ◽  
Sriram Ravindran ◽  
Sri Rahavi Boovarahan ◽  
Gino A. Kurian
Keyword(s):  
Hydrogen Sulfide ◽  
Reperfusion Injury ◽  
Katp Channel ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Rat Hearts ◽  
Significant Difference ◽  
Interfibrillar Mitochondria ◽  
Subsarcolemmal Mitochondria

Hydrogen sulfide has been shown to protect  myocardium against ischemia-reperfusion injury by preserving interfibrillar mitochondria functional activi-ties than subsarcolemmal mitochondria. In this study, the role of the KATP channel in modulating the mitochondrial subpopulations during the cardioprotection mediated by NaSH (H2S donor) was investigated. Isolated rat hearts were treated with mitochondrial KATP channel closer glibenclamide (10 μM)/opener diazoxide (0.8 mM) via Langendorff perfusion apparatus before ischemia-reperfusion. The results showed that NaSH pre-conditioning in presence of glibenclamide significantly improved cardiac recovery without any significant difference between interfibrillar mitochondria and subsarcolemmal mitochondria.  In conclusion, targeting KATP channel may not be good option to target interfibrillar mitochondria/subsarcolemmal mitochondria against ischemia-reperfusion injury.

scholarly journals CaMKII/calpain interaction mediates ischemia/reperfusion injury in isolated rat hearts

2020 ◽  
Vol 11 (5) ◽  
Author(s):  
Hong-Ting Lu ◽  
Ren-Qian Feng ◽  
Jia-Kun Tang ◽  
Jing-Jun Zhou ◽  
Feng Gao ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Rat Hearts ◽  
Isolated Rat

scholarly journals 9-Phenanthrol, a TRPM4 Inhibitor, Protects Isolated Rat Hearts from Ischemia–Reperfusion Injury

PLoS ONE ◽  
2013 ◽  
Vol 8 (7) ◽  
pp. e70587 ◽  
Author(s):  
Jing Wang ◽  
Ken Takahashi ◽  
Hulin Piao ◽  
Peng Qu ◽  
Keiji Naruse
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Rat Hearts ◽  
Isolated Rat
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