Exogenous hydrogen sulfide postconditioning protects isolated rat hearts against ischemia-reperfusion injury

2008 ◽  
Vol 587 (1-3) ◽  
pp. 1-7 ◽  
Author(s):  
Yong Ji ◽  
Qing-feng Pang ◽  
Gang Xu ◽  
Li Wang ◽  
Jun-ke Wang ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Rat Hearts ◽  
Isolated Rat

scholarly journals Hydrogen sulfide-mediated cardioprotection against ischemia reperfusion is linked to KATP channel for mitochondrial preservation but not for its distinct preference on interfibrillar mitochondria

2019 ◽  
Vol 14 (2) ◽  
pp. 107-115 ◽  
Author(s):  
Priyadharshini Chandrasekaran ◽  
Sriram Ravindran ◽  
Sri Rahavi Boovarahan ◽  
Gino A. Kurian
Keyword(s):  
Hydrogen Sulfide ◽  
Reperfusion Injury ◽  
Katp Channel ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Rat Hearts ◽  
Significant Difference ◽  
Interfibrillar Mitochondria ◽  
Subsarcolemmal Mitochondria

Hydrogen sulfide has been shown to protect  myocardium against ischemia-reperfusion injury by preserving interfibrillar mitochondria functional activi-ties than subsarcolemmal mitochondria. In this study, the role of the KATP channel in modulating the mitochondrial subpopulations during the cardioprotection mediated by NaSH (H2S donor) was investigated. Isolated rat hearts were treated with mitochondrial KATP channel closer glibenclamide (10 μM)/opener diazoxide (0.8 mM) via Langendorff perfusion apparatus before ischemia-reperfusion. The results showed that NaSH pre-conditioning in presence of glibenclamide significantly improved cardiac recovery without any significant difference between interfibrillar mitochondria and subsarcolemmal mitochondria.  In conclusion, targeting KATP channel may not be good option to target interfibrillar mitochondria/subsarcolemmal mitochondria against ischemia-reperfusion injury.

scholarly journals CaMKII/calpain interaction mediates ischemia/reperfusion injury in isolated rat hearts

2020 ◽  
Vol 11 (5) ◽  
Author(s):  
Hong-Ting Lu ◽  
Ren-Qian Feng ◽  
Jia-Kun Tang ◽  
Jing-Jun Zhou ◽  
Feng Gao ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Rat Hearts ◽  
Isolated Rat

scholarly journals 9-Phenanthrol, a TRPM4 Inhibitor, Protects Isolated Rat Hearts from Ischemia–Reperfusion Injury

PLoS ONE ◽  
2013 ◽  
Vol 8 (7) ◽  
pp. e70587 ◽  
Author(s):  
Jing Wang ◽  
Ken Takahashi ◽  
Hulin Piao ◽  
Peng Qu ◽  
Keiji Naruse
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Rat Hearts ◽  
Isolated Rat

scholarly journals Sevoflurane post-conditioning protects isolated rat hearts against ischemia-reperfusion injury via activation of the ERK1/2 pathway

2014 ◽  
Vol 35 (12) ◽  
pp. 1504-1513 ◽  
Author(s):  
Hong Xie ◽  
Jing Zhang ◽  
Jiang Zhu ◽  
Li-xin Liu ◽  
Mario Rebecchi ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Rat Hearts ◽  
Isolated Rat

scholarly journals Degradation of Myosin Light Chain in Isolated Rat Hearts Subjected to Ischemia-Reperfusion Injury

Circulation ◽  
2005 ◽  
Vol 112 (4) ◽  
pp. 544-552 ◽  
Author(s):  
Grzegorz Sawicki ◽  
Hernando Leon ◽  
Jolanta Sawicka ◽  
Meltem Sariahmetoglu ◽  
Costas J. Schulze ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Light Chain ◽  
Myosin Light Chain ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Rat Hearts ◽  
Isolated Rat
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