Interleukin-27, a novel cytokine induced by ischemia–reperfusion injury in rat hearts, mediates cardioprotective effects via the gp130/STAT3 pathway

2015 ◽  
Vol 110 (3) ◽  
Author(s):  
Ming-Chieh Ma ◽  
Bao-Wei Wang ◽  
Tzu-Pei Yeh ◽  
Jia-Long Wu ◽  
Tun-Hui Chung ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Stat3 Pathway ◽  
Interleukin 27 ◽  
Rat Hearts ◽  
Cardioprotective Effects

Contribution of Nitric Oxide in Big Endothelin-1–induced Cardioprotective Effects on Ischemia/Reperfusion Injury in Rat Hearts

2011 ◽  
Vol 57 (5) ◽  
pp. 575-578 ◽  
Author(s):  
Masashi Tawa ◽  
Taiki Fukumoto ◽  
Mamoru Ohkita ◽  
Naoto Yamashita ◽  
Ayman Geddawy ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Endothelin 1 ◽  
Rat Hearts ◽  
Cardioprotective Effects

CARDIOPROTECTIVE EFFECTS OF QUERCETIN AGAINST ISCHEMIA-REPERFUSION INJURY IN ISOLATED JUVENILE AND ADULT RAT HEARTS

2018 ◽  
Vol 25 (3) ◽  
pp. 174
Author(s):  
Monika Bartekova ◽  
Kristina Ferenczyova ◽  
Jana Radosinska ◽  
Dezider Pancza ◽  
Miroslav Barancik ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Adult Rat ◽  
Rat Hearts ◽  
Cardioprotective Effects

Cardioprotective Effects of Extracts from Psidium guajava L. and Limonium wrightii, Okinawan Medicinal Plants, against Ischemia-Reperfusion Injury in Perfused Rat Hearts

Pharmacology ◽  
2003 ◽  
Vol 67 (3) ◽  
pp. 128-135 ◽  
Author(s):  
Satoshi Yamashiro ◽  
Katsuhiko Noguchi ◽  
Toshihiro Matsuzaki ◽  
Kanako Miyagi ◽  
Junko Nakasone ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Psidium Guajava ◽  
Rat Hearts ◽  
Perfused Rat Hearts ◽  
Cardioprotective Effects

scholarly journals MicroRNAs associated with ischemia-reperfusion injury and cardioprotection by ischemic pre- and postconditioning: protectomiRs

2014 ◽  
Vol 307 (2) ◽  
pp. H216-H227 ◽  
Author(s):  
Zoltán V. Varga ◽  
Ágnes Zvara ◽  
Nóra Faragó ◽  
Gabriella F. Kocsis ◽  
Márton Pipicz ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Coronary Occlusion ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Expression Patterns ◽  
Microrna Expression ◽  
Rat Hearts ◽  
Male Wistar Rats ◽  
Cardioprotective Effects ◽  
Therapeutic Tools

We aimed to characterize early changes in microRNA expression in acute cardioprotection by ischemic pre- and postconditioning in rat hearts. Hearts isolated from male Wistar rats were subjected to 1) time-matched nonischemic perfusion, 2) ischemia-reperfusion (30 min of coronary occlusion and 120 min of reperfusion), 3) preconditioning (3 × 5 min of coronary occlusion) followed by ischemia-reperfusion, or 4) ischemia-reperfusion with postconditioning (6 × 10 s of global ischemia-reperfusion at the onset of reperfusion). Infarct size was significantly reduced by both interventions. Of 350 different microRNAs assessed by microarray analysis, 147–160 microRNAs showed detectable expression levels. Compared with microRNA alterations induced by ischemia-reperfusion versus time-matched nonischemic controls, five microRNAs were significantly affected by both pre- and postconditioning (microRNA-125b*, microRNA-139-3p, microRNA-320, microRNA-532-3p, and microRNA-188), four microRNAs were significantly affected by preconditioning (microRNA-487b, microRNA-139-5p, microRNA-192, and microRNA-212), and nine microRNAs were significantly affected by postconditioning (microRNA-1, microRNA let-7i, microRNA let-7e, microRNA let-7b, microRNA-181a, microRNA-208, microRNA-328, microRNA-335, and microRNA-503). Expression of randomly selected microRNAs was validated by quantitative real-time PCR. By a systematic comparison of the direction of microRNA expression changes in all groups, we identified microRNAs, specific mimics, or antagomiRs that may have pre- and postconditioning-like cardioprotective effects (protectomiRs). Transfection of selected protectomiRs (mimics of microRNA-139-5p, microRNA-125b*, microRNA let-7b, and inhibitor of microRNA-487b) into cardiac myocytes subjected to simulated ischemia-reperfusion showed a significant cytoprotective effect. This is the first demonstration that the ischemia-reperfusion-induced microRNA expression profile is significantly influenced by both pre- and postconditioning, which shows the involvement of microRNAs in cardioprotective signaling. Moreover, by analysis of microRNA expression patterns in cardioprotection by pre- and postconditioning, specific protectomiRs can be revealed as potential therapeutic tools for the treatment of ischemia-reperfusion injury.

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