Mallory Bodies and Giant Mitochondria-two Different Structures in Liver Biopsies from Alcoholics

1973 ◽  
Vol 150 (3) ◽  
pp. 298-310 ◽  
Author(s):  
L. Bianchi ◽  
K. Winckler ◽  
M. Mihatsch ◽  
H.P. Rohr
Keyword(s):  
Giant Mitochondria ◽  
Mallory Bodies ◽  
Liver Biopsies

Mallory Bodies in Liver Biopsies from Chronic Alcoholics

1973 ◽  
Vol 8 (4) ◽  
pp. 341-346 ◽  
Author(s):  
P. Christoffersen ◽  
K. Eghöje ◽  
E. Juhl
Keyword(s):  
Mallory Bodies ◽  
Liver Biopsies

Hepatic Ultrastructure in Methotrexate Treated Psoriatic Patients

1977 ◽  
Vol 35 ◽  
pp. 520-521
Author(s):  
E. Horvath ◽  
K. Kovacs ◽  
R. C. Ross ◽  
N. A. Kerenyi ◽  
F. G. Saibil
Keyword(s):  
Electron Microscopy ◽  
Folic Acid ◽  
Cell Membrane ◽  
Liver Tissue ◽  
Percutaneous Biopsy ◽  
Giant Mitochondria ◽  
Folic Acid Antagonist ◽  
Zone Cell ◽  
Paracrystalline Inclusions ◽  
Liver Biopsies

Fifty liver biopsies of psoriatic patients treated with methotrexate, a folic acid antagonist, for a period from a few weeks up to 15 years have been studied. Liver tissue has been obtained by percutaneous biopsy with a Menghini needle and prepared for electron microscopy by using conventional techniques.In the hepatocytes, profound changes have been revealed in four areas: nucleus, mitochondria, ectoplasmic zone-cell membrane and desmosomes. The nuclei showed reduced electron opacity and almost complete absence of heterochromatin. Cytoplasmic invaginations and glycogen inclusions were common. Mitochondrial pleomorphism, paracrystalline inclusions and giant mitochondria were prominent findings. Compartmentalization, fission and division of mitochondria were also noted. Sequestration of mitochondria via development of cytosegresomes was observed in several cases. Detachment of desmosomes was a conspicuous finding in 25 of 50 biopsies obtained from methotrexate-treated psoriatics. In these livers many or practically all membrane sites with desmosomal specialization appeared to be pulled apart.

Crystalloid Inclusions in Hepatocyte Mitochondria and Their Similarity to Cytoplasmic Crystalloids

1974 ◽  
Vol 32 ◽  
pp. 198-199
Author(s):  
Odell T. Minick ◽  
Hidejiro Yokoo
Keyword(s):  
Liver Disease ◽  
Alcoholic Liver Disease ◽  
Special Interest ◽  
Structural Variations ◽  
Mitochondrial Alterations ◽  
The Matrix ◽  
Crystalloid Inclusions ◽  
Liver Biopsies

Mitochondrial alterations were studied in 25 liver biopsies from patients with alcoholic liver disease. Of special interest were the morphologic resemblance of certain fine structural variations in mitochondria and crystalloid inclusions. Four types of alterations within mitochondria were found that seemed to relate to cytoplasmic crystalloids.Type 1 alteration consisted of localized groups of cristae, usually oriented in the long direction of the organelle (Fig. 1A). In this plane they appeared serrated at the periphery with blind endings in the matrix. Other sections revealed a system of equally-spaced diagonal lines lengthwise in the mitochondrion with cristae protruding from both ends (Fig. 1B). Profiles of this inclusion were not unlike tangential cuts of a crystalloid structure frequently seen in enlarged mitochondria described below.

Ultrastructure of Giant Mitochondria and Their Inclusions in Schwann Cells of Bovine Splenic Nerve

1974 ◽  
Vol 32 ◽  
pp. 194-195
Author(s):  
Å. Thureson-Klein
Keyword(s):  
Schwann Cells ◽  
Cell Organelles ◽  
Giant Mitochondria ◽  
Matrix Density ◽  
Physiological Conditions ◽  
Unmyelinated Axons ◽  
Internal Structures ◽  
Structural Abnormalities ◽  
Cytotoxic Compounds ◽  
Cell Components

Giant mitochondria of various shapes and with different internal structures and matrix density have been observed in a great number of tissues including nerves. In most instances, the presence of giant mitochondria has been associated with a known disease or with abnormal physiological conditions such as anoxia or exposure to cytotoxic compounds. In these cases degenerative changes occurred in other cell organelles and, therefore the giant mitochondria also were believed to be induced structural abnormalities.Schwann cells ensheating unmyelinated axons of bovine splenic nerve regularly contain giant mitochondria in addition to the conventional smaller type (Fig. 1). These nerves come from healthy inspected animals presumed not to have been exposed to noxious agents. As there are no drastic changes in the small mitochondria and because other cell components also appear reasonably well preserved, it is believed that the giant mitochondria are normally present jin vivo and have not formed as a post-mortem artifact.

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