Adult human microglia secrete cytokines when exposed to neurotoxic prion protein peptide: no intermediary role for prostaglandin E2

2002 ◽  
Vol 925 (2) ◽  
pp. 195-203 ◽  
Author(s):  
Robert Veerhuis ◽  
Jeroen J.M Hoozemans ◽  
Ingrid Janssen ◽  
Ronald S Boshuizen ◽  
Jan P.M Langeveld ◽  
...  
Keyword(s):  
Prostaglandin E2 ◽  
Prion Protein ◽  
Human Microglia ◽  
Adult Human ◽  
Intermediary Role ◽  
Prion Protein Peptide

scholarly journals Altered toxicity of the prion protein peptide PrP106–126 carrying the Ala117→Val mutation

2000 ◽  
Vol 346 (3) ◽  
pp. 785-791 ◽  
Author(s):  
David R. BROWN
Keyword(s):  
Point Mutation ◽  
Prion Protein ◽  
Prion Diseases ◽  
Point Mutations ◽  
Human Sequence ◽  
Gene Coding ◽  
Normal Human ◽  
Microtubule Formation ◽  
Β Sheet ◽  
Prion Protein Peptide

The inherited prion diseases such as Gerstmann-Sträussler-Scheinker syndrome (GSS) are linked to point mutations in the gene coding for the cellular isoform of the prion protein (PrPC). One particular point mutation A117V (Ala117 → Val) is linked to a variable pathology that usually includes deposition of neurofibrillary tangles. A prion protein peptide carrying this point mutation [PrP106-126(117V)] was generated and compared with a peptide based on the normal human sequence [PrP106-126(117A)]. The inclusion of this point mutation increased the toxicity of PrP106-126 which could be linked to an increased β-sheet content. An assay of microtubule formation in the presence of tau indicated that PrP106-126 decreased the rate of microtubule formation that could be related to the displacement of tau. PrP106-126 carrying the 117 mutation was more efficient at inhibiting microtubule formation. These results suggest a possible mechanism of toxicity for protein carrying this mutation via destabilization of the cytoskeleton and deposition of tau in filaments, as observed in GSS.

B7/BB-1 antigen expression on adult human microglia studiedin vitro andin situ

1994 ◽  
Vol 24 (12) ◽  
pp. 3031-3037 ◽  
Author(s):  
Kenneth Williams ◽  
Elling Ulvestad ◽  
Jack P. Antel
Keyword(s):  
Antigen Expression ◽  
Human Microglia ◽  
Adult Human

scholarly journals Postmortem Adult Human Microglia Proliferate in Culture to High Passage and Maintain Their Response to Amyloid-β

2016 ◽  
Vol 54 (3) ◽  
pp. 1157-1167 ◽  
Author(s):  
Ling Guo ◽  
Aras Rezvanian ◽  
Lokesh Kukreja ◽  
Ramez Hoveydai ◽  
Eileen H. Bigio ◽  
...  
Keyword(s):  
Amyloid Β ◽  
High Passage ◽  
Human Microglia ◽  
Adult Human

scholarly journals A human prion protein peptide (PrP59–91) protects against copper neurotoxicity

2003 ◽  
Vol 8 (10) ◽  
pp. 835-835 ◽  
Author(s):  
M A Chacón ◽  
M I Barría ◽  
R Lorca ◽  
J P Huidobro-Toro ◽  
N C Inestrosa
Keyword(s):  
Prion Protein ◽  
Human Prion Protein ◽  
Prion Protein Peptide

Cellular effects of a neurotoxic prion protein peptide are related to its ?-sheet content

1998 ◽  
Vol 23 (2) ◽  
pp. 119-128 ◽  
Author(s):  
David R. Brown ◽  
Martin Pitschke ◽  
Detlev Riesner ◽  
Hans A. Kretzschmar
Keyword(s):  
Prion Protein ◽  
Cellular Effects ◽  
Prion Protein Peptide

scholarly journals Pharmacological activation of autophagy favors the clearing of intracellular aggregates of misfolded prion protein peptide to prevent neuronal death

2018 ◽  
Vol 9 (2) ◽  
Author(s):  
Stefano Thellung ◽  
Beatrice Scoti ◽  
Alessandro Corsaro ◽  
Valentina Villa ◽  
Mario Nizzari ◽  
...  
Keyword(s):  
Prion Protein ◽  
Neuronal Death ◽  
Intracellular Aggregates ◽  
Prion Protein Peptide

scholarly journals An Antibody to the Aggregated Synthetic Prion Protein Peptide (PrP106-126) Selectively Recognizes Disease-Associated Prion Protein (PrPSc) from Human Brain Specimens

2009 ◽  
Vol 19 (2) ◽  
pp. 293-302 ◽  
Author(s):  
Michael Jones ◽  
Darren Wight ◽  
Victoria McLoughlin ◽  
Katherine Norrby ◽  
James W. Ironside ◽  
...  
Keyword(s):  
Human Brain ◽  
Prion Protein ◽  
Prion Protein Peptide

Oligopeptide-Mediated Stabilization of the α-Helix of a Prion Protein Peptide

2000 ◽  
Vol 122 (50) ◽  
pp. 12596-12597 ◽  
Author(s):  
Yoshihiro Kuroda ◽  
Yoshitaka Maeda ◽  
Terumichi Nakagawa
Keyword(s):  
Prion Protein ◽  
Α Helix ◽  
Prion Protein Peptide
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