B7/BB-1 antigen expression on adult human microglia studiedin vitro andin situ

1994 ◽  
Vol 24 (12) ◽  
pp. 3031-3037 ◽  
Author(s):  
Kenneth Williams ◽  
Elling Ulvestad ◽  
Jack P. Antel
Keyword(s):  
Antigen Expression ◽  
Human Microglia ◽  
Adult Human

scholarly journals Postmortem Adult Human Microglia Proliferate in Culture to High Passage and Maintain Their Response to Amyloid-β

2016 ◽  
Vol 54 (3) ◽  
pp. 1157-1167 ◽  
Author(s):  
Ling Guo ◽  
Aras Rezvanian ◽  
Lokesh Kukreja ◽  
Ramez Hoveydai ◽  
Eileen H. Bigio ◽  
...  
Keyword(s):  
Amyloid Β ◽  
High Passage ◽  
Human Microglia ◽  
Adult Human

Amyloid β plaque-associated proteins C1q and SAP enhance the Aβ1–42 peptide-induced cytokine secretion by adult human microglia in vitro

2003 ◽  
Vol 105 (2) ◽  
pp. 135-144 ◽  
Author(s):  
Robert Veerhuis ◽  
Mariëlle J. Van Breemen ◽  
Jeroen J. Hoozemans ◽  
Michela Morbin ◽  
Jamal Ouladhadj ◽  
...  
Keyword(s):  
Amyloid Β ◽  
Cytokine Secretion ◽  
Human Microglia ◽  
Adult Human ◽  
Associated Proteins

Obtaining Human Microglia from Adult Human Brain Tissue

10.3791/61438 ◽  
2020 ◽  
Author(s):  
Ishan Agrawal ◽  
Shivanjali Saxena ◽  
Preethika Nair ◽  
Deepak Jha ◽  
Sushmita Jha
Keyword(s):  
Human Brain ◽  
Brain Tissue ◽  
Human Brain Tissue ◽  
Adult Human Brain ◽  
Human Microglia ◽  
Adult Human

Biology of Adult Human Microglia in Culture: Comparisons with Peripheral Blood Monocytes and Astrocytes

1992 ◽  
Vol 51 (5) ◽  
pp. 538-549 ◽  
Author(s):  
Kenneth Williams ◽  
Amit Bar-Or ◽  
Elling Ulvestad ◽  
Andre Olivier ◽  
Jack P. Antel ◽  
...  
Keyword(s):  
Peripheral Blood ◽  
Blood Monocytes ◽  
Peripheral Blood Monocytes ◽  
Human Microglia ◽  
Adult Human

scholarly journals IL-38 inhibits microglial inflammatory mediators and is decreased in amygdala of children with autism spectrum disorder

2020 ◽  
Vol 117 (28) ◽  
pp. 16475-16480 ◽  
Author(s):  
Irene Tsilioni ◽  
Harry Pantazopoulos ◽  
Pio Conti ◽  
Susan E. Leeman ◽  
Theoharis C. Theoharides
Keyword(s):  
Autism Spectrum Disorder ◽  
Social Interactions ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
University Of Maryland ◽  
Human Microglia ◽  
Adult Human ◽  
Children With Asd ◽  
The University

Autism spectrum disorder (ASD) is characterized by impaired social interactions and communication. The pathogenesis of ASD is not known, but it involves activation of microglia. We had shown that the peptide neurotensin (NT) is increased in the serum of children with ASD and stimulates cultured adult human microglia to secrete the proinflammatory molecules IL-1β and CXCL8. This process is inhibited by the cytokine IL-37. Another cytokine, IL-38, has been reported to have antiinflammatory actions. In this report, we show that pretreatment of cultured adult human microglia with recombinant IL-38 (aa3-152, 1–100 ng/mL) inhibits (P< 0.0001) NT-stimulated (10 nM) secretion of IL-1β (at 1 ng/mL) and CXCL8 (at 100 ng/mL). In fact, IL-38 (aa3-152, 1 ng/mL) is more potent than IL-37 (100 ng/mL). Here, we report that pretreatment with IL-38 (100 ng/mL) of embryonic microglia (HMC3), in which secretion of IL-1β was undetectable, inhibits secretion of CXCL8 (P= 0.004). Gene expression of IL-38 and its receptor IL-36R are decreased (P= 0.001 andP= 0.04, respectively) in amygdala from patients with ASD (n= 8) compared to non-ASD controls (n= 8), obtained from the University of Maryland NeuroBioBank. IL-38 is increased (P= 0.03) in the serum of children with ASD. These findings indicate an important role for IL-38 in the inhibition of activation of human microglia, thus supporting its development as a treatment approach for ASD.

Interferon-β impairs induction of HLA-DR antigen expression in cultured adult human astrocytes

1989 ◽  
Vol 23 (1) ◽  
pp. 45-53 ◽  
Author(s):  
Barbara P. Barna ◽  
Samuel M. Chou ◽  
Barbara Jacobs ◽  
Belinda Yen-Lieberman ◽  
Richard M. Ransohoff
Keyword(s):  
Antigen Expression ◽  
Interferon Β ◽  
Adult Human ◽  
Human Astrocytes ◽  
Hla Dr

Transforming Growth Factor-β1 in Adult Human Microglia and Its Stimulated Production by Interleukin-1

1997 ◽  
Vol 17 (11) ◽  
pp. 655-664 ◽  
Author(s):  
ANNA DA CUNHA ◽  
JANE J. JEFFERSON ◽  
WILLIAM R. TYOR ◽  
JONATHAN D. GLASS ◽  
FRANK S. JANNOTTA ◽  
...  
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor ◽  
Interleukin 1 ◽  
Transforming Growth Factor Β1 ◽  
Human Microglia ◽  
Adult Human
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