Matrix metalloproteinase-9 (MMP-9) enhances leukocyte trafficking and alveolar capillary leakage in pancreatitis-associated lung injury by basement membrane digestion

2001 ◽  
Vol 120 (5) ◽  
pp. A111-A111
Author(s):  
T KECK ◽  
J BALCOMIV ◽  
B ANTONIU ◽  
C FERNANDEZDELCASTILLO ◽  
A WARSHAW
Keyword(s):  
Basement Membrane ◽  
Lung Injury ◽  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 9 ◽  
Leukocyte Trafficking ◽  
Capillary Leakage ◽  
Metalloproteinase 9 ◽  
Alveolar Capillary

Matrix metalloproteinase-9 promotes neutrophil migration and alveolar capillary leakage in pancreatitis-associated lung injury in the rat

2002 ◽  
Vol 122 (1) ◽  
pp. 188-201 ◽  
Author(s):  
Tobias Keck ◽  
James H. Balcom ◽  
Carlos Fernández–Del Castillo ◽  
Bozena A. Antoniu ◽  
Andrew L. Warshaw
Keyword(s):  
Lung Injury ◽  
Matrix Metalloproteinase ◽  
Neutrophil Migration ◽  
Matrix Metalloproteinase 9 ◽  
Capillary Leakage ◽  
Metalloproteinase 9 ◽  
Alveolar Capillary

scholarly journals Binding of Pro-Matrix Metalloproteinase 9 by Fusobacterium nucleatum subsp. nucleatum as a Mechanism To Promote the Invasion of a Reconstituted Basement Membrane

2004 ◽  
Vol 72 (10) ◽  
pp. 6160-6163 ◽  
Author(s):  
Renée Gendron ◽  
Pascale Plamondon ◽  
Daniel Grenier
Keyword(s):  
Basement Membrane ◽  
Matrix Metalloproteinase ◽  
Colorimetric Assay ◽  
Active Form ◽  
Fusobacterium Nucleatum ◽  
Matrix Metalloproteinase 9 ◽  
Enzyme Linked Immunosorbent Assay ◽  
Potential Contribution ◽  
Invasive Potential ◽  
Metalloproteinase 9

ABSTRACT In this study, we investigated the ability of Fusobacterium nucleatum subsp. nucleatum to increase its tissue-invasive potential by acquiring cell-associated human matrix metalloproteinase 9 (MMP-9) activity. Binding of pro-MMP-9 to fusobacteria was demonstrated by enzyme-linked immunosorbent assay. Zymography and a colorimetric assay showed that bound pro-MMP-9 can be converted into a proteolytically active form. The potential contribution of this acquired host activity in tissue invasion was demonstrated using a reconstituted basement membrane (Matrigel).

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