Oral contraceptives worsen endotoxin induced liver injury in rats

Oral contraceptives have long been associated with liver injury. However, very little attention is paid to the metabolic side effects of hormone-releasing intrauterine devices (IUDs). These devices are generally considered safe and commonly used. We report for the first time acute liver injury associated with a levonorgestrel-releasing IUD. Our patient did not have any comorbidities that could have caused or exacerbated liver injury. A detailed workup and liver biopsy remained negative for any other potential cause of liver injury. The patient’s symptoms resolved with removal of the device. She remained symptom free on subsequent outpatient follow-ups.

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Oral Contraceptives Worsen Endotoxin-Induced Liver Injury in Rats

Alcoholism Clinical and Experimental Research ◽

10.1111/j.1530-0277.2002.tb02706.x ◽

2002 ◽

Vol 26 (s1) ◽

pp. 70s-74s ◽

Cited By ~ 7

Author(s):

Akira Konno ◽

Nobuyuki Enomoto ◽

Yoshiyuki Takei ◽

Miyoko Hirose ◽

Kenichi Ikejima ◽

...

Keyword(s):

Liver Injury ◽

Oral Contraceptives

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Effects of Steroids on Fetal Rat Liver

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100063664 ◽

1969 ◽

Vol 27 ◽

pp. 350-351

Author(s):

F. G. Zaki

Keyword(s):

Liver Injury ◽

Rat Liver ◽

Fetal Liver ◽

Dosage Level ◽

Maternal Plasma ◽

Methyl Prednisolone ◽

Fetal Rat ◽

Toxic Agents ◽

Fetal Rat Liver ◽

Neonatal Liver

Fetal and neonatal liver injury induced by agents circulating in maternal plasma, even though well recognized, its morphological manifestations are not yet established. As part of our studies of fetal and neonatal liver injury induced by maternal nutritional disorders, metabolic impairment and toxic agents, the effects of two anti-inflammatory steroids have been recently inves tigated.Triamcinolone and methyl prednisolone were injected each in a group of rats during pregnancy at a-dosage level of 2 mgm three times a week. Fetal liver was studied at 18 days of gestation. Litter size and weight markedly decreased than those of control rats. Stillbirths and resorption were of higher incidence in the triamcinolone group than in those given the prednisolone.

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