Role of vanilloid receptor 1 (VR1) in increased nociceptive signaling in experimental pancreatitis

2001 ◽  
Vol 120 (5) ◽  
pp. A179-A179
Author(s):  
L ZOU ◽  
M SHENOY ◽  
J WINSTON ◽  
P PASRICHA
2001 ◽  
Vol 120 (5) ◽  
pp. A179
Author(s):  
Lei Zou ◽  
Mohan Shenoy ◽  
John H. Winston ◽  
Pankaj J. Pasricha

2003 ◽  
Vol 23 (4) ◽  
pp. 1340-1350 ◽  
Author(s):  
Viktorie Vlachová ◽  
Jan Teisinger ◽  
Klára Sušánková ◽  
Alla Lyfenko ◽  
Rüdiger Ettrich ◽  
...  

2001 ◽  
Vol 281 (5) ◽  
pp. G1322-G1328 ◽  
Author(s):  
Jaimie D. Nathan ◽  
Akash A. Patel ◽  
Douglas C. McVey ◽  
Jean E. Thomas ◽  
Veronica Prpic ◽  
...  

We examined whether the capsaicin vanilloid receptor-1 (VR1) mediates substance P (SP) release from primary sensory neurons in experimental pancreatitis. Pancreatitis was achieved by 12 hourly injections of caerulein (50 μg/kg ip) in mice. One group received capsazepine (100 μmol/kg sc), a competitive VR1 antagonist, at 4-h intervals. Neurokinin-1 receptor (NK1R) internalization in acinar cells, used as an index of endogenous SP release, was assessed by immunocytochemical quantification of NK1R endocytosis. The severity of pancreatitis was assessed by measurements of serum amylase, pancreatic myeloperoxidase (MPO) activity, and histological grading. Caerulein administration caused significant elevations in serum amylase and pancreatic MPO activity, produced histological evidence of pancreatitis, and caused a dramatic increase in NK1R endocytosis. Capsazepine treatment significantly reduced the level of NK1R endocytosis, and this was associated with similar reductions in pancreatic MPO activity and histological severity of pancreatitis. These results demonstrate that repeated caerulein stimulation causes experimental pancreatitis that is mediated in part by stimulation of VR1 on primary sensory neurons, resulting in endogenous SP release.


2005 ◽  
Vol 15 (23) ◽  
pp. 5211-5217 ◽  
Author(s):  
Ning Xi ◽  
Yunxin Bo ◽  
Elizabeth M. Doherty ◽  
Christopher Fotsch ◽  
Narender R. Gavva ◽  
...  

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