Helicobacter pylori infection affects oxygen free radicals generation and oxidative DNA damage in gastric mucosa

2001 ◽  
Vol 120 (5) ◽  
pp. A656-A657
Author(s):  
Alfredo Papa ◽  
Silvio Danese ◽  
Alessandro Sgambato ◽  
Raffaele Ardito ◽  
Antonino Grillo ◽  
...  
Keyword(s):  
Dna Damage ◽  
Helicobacter Pylori ◽  
Free Radicals ◽  
Gastric Mucosa ◽  
Oxidative Dna Damage ◽  
Oxygen Free Radicals ◽  
Helicobacter Pylori Infection

Helicobacter pylori infection CagA-positive increases the oxidative DNA damage of gastric mucosa

2000 ◽  
Vol 32 ◽  
pp. A65
Author(s):  
R. Cardin ◽  
M. Franco ◽  
V. Russo ◽  
G. Busatto ◽  
M. Rugge ◽  
...  
Keyword(s):  
Dna Damage ◽  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Oxidative Dna Damage ◽  
Helicobacter Pylori Infection

scholarly journals Association of Helicobacter Pylori Infection with Oxidative DNA Damage and Atherosclerosis in Rheumatoid Arthritis Patients

2017 ◽  
Vol 06 (02) ◽  
Author(s):  
Doaa Waseem Nada ◽  
Amal Mohamad El Barbary ◽  
Sally Abd El monem El Nawasany ◽  
Rasha Ahmed Gaber ◽  
Radwa Mahmoud El sharaby ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Dna Damage ◽  
Helicobacter Pylori ◽  
Oxidative Dna Damage ◽  
Helicobacter Pylori Infection

Helicobacter pylori CagA+ve infection increases the oxidative DNA damage of gastric mucosa

2000 ◽  
Vol 118 (4) ◽  
pp. A182
Author(s):  
Romilda Cardin ◽  
Valentina Russo ◽  
Graziella Busatto ◽  
Massimo Rugge ◽  
Fabio Farinati
Keyword(s):  
Dna Damage ◽  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Oxidative Dna Damage

Role of Helicobacter pylori CagA + Infection in Determining Oxidative DNA Damage in Gastric Mucosa

2002 ◽  
Vol 37 (4) ◽  
pp. 409-413 ◽  
Author(s):  
A. Papa ◽  
S. Danese ◽  
A. Sgambato ◽  
R. Ardito ◽  
G. Zannoni ◽  
...  
Keyword(s):  
Dna Damage ◽  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Oxidative Dna Damage

scholarly journals Interplay between Helicobacter pylori and host gene polymorphisms in inducing oxidative DNA damage in the gastric mucosa

2006 ◽  
Vol 28 (4) ◽  
pp. 892-898 ◽  
Author(s):  
A. Izzotti ◽  
S. De Flora ◽  
C. Cartiglia ◽  
B. M. Are ◽  
M. Longobardi ◽  
...  
Keyword(s):  
Dna Damage ◽  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Gene Polymorphisms ◽  
Oxidative Dna Damage ◽  
Host Gene

scholarly journals Helicobacter pylori infection can modulate the susceptibility of gastric mucosa cells to MNNG

2006 ◽  
Vol 11 (4) ◽  
Author(s):  
Michał Arabski ◽  
Paweł Kazmierczak ◽  
Maria Wiśniewska-Jarosińska ◽  
Zbigniew Morawiec ◽  
Alina Morawiec-Bajda ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Dna Damage ◽  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Comet Assay ◽  
Dietary Factors ◽  
Helicobacter Pylori Infection ◽  
Human Gastric Mucosa ◽  
Alkaline Comet Assay ◽  
H Pylori

AbstractThe pathogenesis of stomach cells can be associated with their susceptibility to exogenous dietary irritants, like nitrosamines such as dimethylnitrosamines (DMNA), and to the effects of non-dietary factors, including Helicobacter pylori infection. We used N-methyl-N’-nitro N-nitrosoguanidyne (MNNG) as a surrogate agent that induces a spectrum of DNA damage similar to DMNA. Using the alkaline comet assay, we showed that antioxidants — vitamins C and E, quercetin, and melatonin — reduced the genotoxic effect of MNNG in H. pylori-infected and non-infected human gastric mucosa cells (GMCs). To compare the sensitivity of the stomach and the blood, the experiment was also carried out in peripheral blood. We observed a higher level of DNA damage induced by MNNG in H. pylori-infected than in noninfected GMCs. We did not note any difference in the efficacy of the repair of the damage in either type of GMC. H. pylori infection may play an important role in the pathogenesis of GMCs, as it can modulate their susceptibility to dietary mutagens/carcinogens, thus contributing to gastric cancer.

Helicobacter pylori CagA-positive Strains Affect Oxygen Free Radicals Generation by Gastric Mucosa

2001 ◽  
Vol 36 (3) ◽  
pp. 247-250 ◽  
Author(s):  
S. Danese ◽  
F. Cremonini ◽  
A. Armuzzi ◽  
M. Candelli ◽  
A. Papa ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Free Radicals ◽  
Gastric Mucosa ◽  
Oxygen Free Radicals
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