Gastric Cancer
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Author(s):  
Yoko Taminishi-Katsuragawa ◽  
Yuji Shimura ◽  
Yu inoue ◽  
Yayoi Matsumura-Kimoto ◽  
Taku Tsukamoto ◽  
...  

2021 ◽  
Vol 226 ◽  
pp. 113896
Author(s):  
Bo Wang ◽  
Qiu-Hua Zhang ◽  
Xiao-Jing Li ◽  
Sai-Qi Wang ◽  
Xiao-Bing Chen ◽  
...  

2021 ◽  
Vol 580 ◽  
pp. 93-99
Author(s):  
Moon Hwa Kwak ◽  
Seung Mok Yang ◽  
Seul Ki Yun ◽  
Sol Kim ◽  
Myung-Gyu Choi ◽  
...  

2021 ◽  
Vol 27 (4) ◽  
pp. 588-595
Author(s):  
Yonsoo Kim ◽  
Young Min Kim ◽  
Jie-Hyun Kim ◽  
Young Hoon Youn ◽  
Jong Won Kim ◽  
...  

2021 ◽  
Vol 9 (29) ◽  
pp. 8718-8728
Author(s):  
Peng Jin ◽  
Hao Liu ◽  
Fu-Hai Ma ◽  
Shuai Ma ◽  
Yang Li ◽  
...  

2021 ◽  
Vol 144 ◽  
pp. 112222
Author(s):  
Xianyu Hu ◽  
Zhenglin Wang ◽  
Qing Wang ◽  
Ke Chen ◽  
Qijun Han ◽  
...  

2021 ◽  
Vol 30 (3) ◽  
pp. 150-157
Author(s):  
Seyit Ahmet Ertürk ◽  
Zekiye Hasbek ◽  
Hatice Özer

2021 ◽  
Vol 13 (10) ◽  
pp. 1367-1382
Author(s):  
Yu-Han Chen ◽  
Chun-Lan Li ◽  
Wen-Jia Chen ◽  
Jing Liu ◽  
Hua-Tao Wu

2021 ◽  
pp. 1-12
Author(s):  
Yanjie You ◽  
Shengjuan Hu

BACKGROUND: We have previously characterized esophageal carcinoma-related gene 4 (ECRG4) as a novel tumor suppressor gene, which is frequently inactivated in nasopharyngeal carcinoma and breast cancer. Nevertheless, the expression status and prognostic significance of ECRG4 maintain elusive in human gastric cancer. Herein, we examined ECRG4 expression profile in gastric cancer and assessed its association with clinicopathological characteristics and patient survival. METHODS: Online data mining, real-time RT-PCR and immunohistochemistry were employed to determined ECRG4 expression at transcriptional and protein levels in tumors vs. noncancerous tissues. Statistical analyses including the Kaplan-Meier survival analysis and the Cox hazard model were utilized to detect the impact on clinical outcome. Moreover, ECRG4 expression was silenced in gastric cancer SGC7901 cells, and cell proliferation, colony formation and invasion assays were carried out. RESULTS: ECRG4 mRNA and protein levels were obviously downregulated in cancer tissues than noncancerous tissues. Statistical analyses demonstrated that low ECRG4 expression was found in 34.5% (58/168) of primary gastric cancer tissues, which was associated with higher histological grade (P= 0.018), lymph node metastasis (P= 0.011), invasive depth (P= 0.020), advanced tumor stage (P= 0.002) and poor overall survival (P< 0.001). Multivariate analysis showed ECRG4 expression is an independent prognostic predictor (P< 0.001). Silencing ECRG4 expression promoted gastric cancer cell growth and invasion. Western blot analysis revealed the anti-metastatic functions of ECRG4 by downregulating of E-cadherin and α-Catenin, as well as upregulating N-cadherin and Vimentin. CONCLUSIONS: Our observations reveal that ECRG4 expression is involved in gastric cancer pathogenesis and progression, and may serve as a candidate prognostic biomarker for this disease.


Author(s):  
Tsutomu Namikawa ◽  
Shigeto Shimizu ◽  
Keiichiro Yokota ◽  
Nobuhisa Tanioka ◽  
Masaya Munekage ◽  
...  

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