Sa2040 – Vitamin B12 Malabsorption and Deficiency Following Restorative Proctocolectomy. A Systematic Review and Meta-Analysis

Abstract Context Some evidence has shown an association between maternal vitamin B12 levels and the development of preeclampsia in pregnant women, but the relationship between preeclampsia and vitamin B12 is not clear. Objective The aim of this systematic review was to compare serum vitamin B12 levels in women with preeclampsia with those in normotensive pregnant women. Data Sources The PubMed/MEDLINE, Scopus, and Web of Science databases were searched up to August 2019, along with the reference lists of included articles. Study Selection The literature was searched for observational studies that investigated vitamin B12 levels in women with preeclampsia. Data Extraction Data were extracted independently by 2 authors. Data were pooled using a random-effects model. Results Vitamin B12 levels in women with preeclampsia were significantly lower than those in healthy women (mean, −15.24 pg/mL; 95%CI, −27.52 to −2.954; P < 0.015), but heterogeneity between studies was high (I2 = 97.8%; P = 0.0103). Subgroup analyses based on folic acid supplementation, homocysteine concentrations, and gestational age at the time of sampling for vitamin B12 assessment did not identify the sources of heterogeneity. Conclusions Women with preeclampsia had significantly lower vitamin B12 concentrations than normotensive pregnant women.

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Oxcarbazepine administration and the serum levels of homocysteine, vitamin B12 and folate in epileptic patients: A systematic review and meta-analysis

Seizure ◽

10.1016/j.seizure.2016.11.016 ◽

2017 ◽

Vol 45 ◽

pp. 87-94 ◽

Cited By ~ 4

Author(s):

Shahabeddin Rezaei ◽

Sakineh Shab-Bidar ◽

Ahmed Abdulahi Abdurahman ◽

Kurosh Djafarian

Keyword(s):

Systematic Review ◽

Vitamin B12 ◽

Meta Analysis ◽

Serum Levels ◽

Epileptic Patients

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Modified two-stage restorative proctocolectomy with ileal pouch-anal anastomosis for ulcerative colitis: a systematic review and meta-analysis of observational research

International Journal of Colorectal Disease ◽

10.1007/s00384-020-03696-7 ◽

2020 ◽

Vol 35 (10) ◽

pp. 1817-1830

Author(s):

William Yu Luo ◽

Siddharth Singh ◽

Raphael Cuomo ◽

Samuel Eisenstein

Keyword(s):

Systematic Review ◽

Ulcerative Colitis ◽

Restorative Proctocolectomy ◽

Ileal Pouch ◽

Meta Analysis ◽

Ileal Pouch Anal Anastomosis ◽

Observational Research ◽

Two Stage ◽

Anal Anastomosis

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Vitamin B12, B6, or Folate and Cognitive Function in Community-Dwelling Older Adults: A Systematic Review and Meta-Analysis

Journal of Alzheimer s Disease ◽

10.3233/jad-200534 ◽

2020 ◽

Vol 77 (2) ◽

pp. 781-794 ◽

Cited By ~ 1

Author(s):

Chenbo Zhang ◽

Jianfeng Luo ◽

Changzheng Yuan ◽

Ding Ding

Keyword(s):

Systematic Review ◽

Older Adults ◽

Cognitive Function ◽

Cognitive Decline ◽

Vitamin B12 ◽

Prospective Studies ◽

Meta Analysis ◽

Community Dwelling ◽

Sensitivity Analyses ◽

Community Dwelling Older Adults

Background: Previous studies have indicated that B vitamin deficiencies are an essential cause of neurological pathology. There is a need to provide evidence of the benefit of B vitamins for the prevention of cognitive decline in community-dwelling older adults. Objective: To examine the association between intake and plasma levels of vitamins B12, B6, and folate and cognitive function in older populations through a systematic review and meta-analysis. Methods: Medline (PubMed), EMBASE, and Cochrane databases were used to search the literature though August 8, 2019. We included observational population-based studies evaluating the association between concentrations or intake levels of vitamins B6, B12, or folate and cognition in older adults aged ≥45 years. The quality of all studies was assessed by the modified Newcastle-Ottawa Scale. Odds ratios (ORs) and hazard ratios (HRs) were analyzed by the random-effects model. Sensitivity analyses were conducted by excluding the studies with significant heterogeneity. Results: Twenty-one observational studies with sample sizes ranging from 155–7030 were included in the meta-analysis. Higher levels of vitamin B12 (OR = 0.77, 95% CI = 0.61–0.97) and folate concentration (OR = 0.68, 95% CI = 0.51–0.90) were associated with better cognition in cross-sectional studies, but not in sensitivity analyses or prospective studies. High vitamin B6 concentrations showed no significant benefit on cognition and dementia risk. Prospective studies did not provide substantial evidence for the relationship. Conclusion: The results from our meta-analysis suggest that vitamins B12, B6, and folate may not be modifiable risk factors for slowing cognitive decline among community-dwelling older individuals.

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