scholarly journals Anxiolytic effect of serotonergic drugs in the conditioned fear stress model

1997 ◽  
Vol 73 ◽  
pp. 24
Author(s):  
Takeshi Inone ◽  
Tsukasa Koyama
Keyword(s):  
Conditioned Fear ◽  
Anxiolytic Effect ◽  
Stress Model ◽  
Conditioned Fear Stress ◽  
Serotonergic Drugs

Asenapine reduces anxiety-related behaviours in rat conditioned fear stress model

2016 ◽  
Vol 28 (6) ◽  
pp. 327-336 ◽  
Author(s):  
Masayo Ohyama ◽  
Maho Kondo ◽  
Miki Yamauchi ◽  
Taiichiro Imanishi ◽  
Tsukasa Koyama
Keyword(s):  
Receptor Antagonist ◽  
Partial Agonist ◽  
Conditioned Fear ◽  
Serotonin Release ◽  
Rat Hippocampus ◽  
Stress Model ◽  
Electrical Shock ◽  
Conditioned Fear Stress ◽  
Skinner Box

ObjectiveAsenapine is an atypical antipsychotic that is currently available for the treatment of schizophrenia and bipolar I disorder. Although the atypical antipsychotics clozapine and olanzapine are effective for depression and anxiety in schizophrenia, as demonstrated by animal model studies, this has not been clarified for asenapine. Therefore, we compared the effects of asenapine in the conditioned fear stress model with those of clozapine and olanzapine.MethodRats were individually fear conditioned using electrical foot shock in a Skinner box. Approximately 24 h later, individual animals were returned to the same Skinner box (without electrical shock) and their freezing behaviour was observed for 5 min. Animals were treated with asenapine, clozapine, olanzapine, the 5-HT1A receptor partial agonist buspirone, or the 5-HT2C receptor antagonist SB242084 at 30 min before freezing behaviour assessment. The 5-HT1A receptor antagonist WAY100635 or the 5-HT2C receptor agonist Ro60-0175 was also used concomitantly with asenapine. The effects of asenapine, clozapine, and olanzapine on serotonin release in the rat hippocampus were also measured using in vivo microdialysis.ResultsAsenapine reduced freezing behaviour, while neither clozapine nor olanzapine reduced freezing behaviour. Buspirone and SB242084 also reduced freezing behaviour. The effect of asenapine in reducing freezing behaviour was not altered by the concomitant administration of WAY100635 or Ro60-0175. Both asenapine and clozapine, but not olanzapine, increased serotonin release in the rat hippocampus.ConclusionAsenapine may have superior therapeutic effect on anxiety symptoms than other agents, although the underlying mechanism of its anxiolytic activity remains unknown.

The effects of the co-administration of the α1-adrenoreceptor antagonist prazosin on the anxiolytic effect of citalopram in conditioned fear stress in the rat

2012 ◽  
Vol 39 (1) ◽  
pp. 107-111 ◽  
Author(s):  
Naoki Takamura ◽  
Takahiro Masuda ◽  
Takeshi Inoue ◽  
Shin Nakagawa ◽  
Tsukasa Koyama
Keyword(s):  
Conditioned Fear ◽  
Anxiolytic Effect ◽  
Conditioned Fear Stress

Fluoxetine reduces periodontal disease progression in a conditioned fear stress model in rats

2013 ◽  
Vol 48 (5) ◽  
pp. 632-637 ◽  
Author(s):  
J. C. A. Aguiar ◽  
E. P. P. Gomes ◽  
T. Fonseca-Silva ◽  
N. A. Velloso ◽  
L. T. Vieira ◽  
...  
Keyword(s):  
Periodontal Disease ◽  
Disease Progression ◽  
Conditioned Fear ◽  
Stress Model ◽  
Conditioned Fear Stress

Anxiolytic-like profile of mirtazapine in rat conditioned fear stress model: Functional significance of 5-hydroxytryptamine 1A receptor and α1-adrenergic receptor

2009 ◽  
Vol 92 (3) ◽  
pp. 393-398 ◽  
Author(s):  
Nobukazu Kakui ◽  
Fumikazu Yokoyama ◽  
Miki Yamauchi ◽  
Koichi Kitamura ◽  
Taiichiro Imanishi ◽  
...  
Keyword(s):  
Functional Significance ◽  
Adrenergic Receptor ◽  
Conditioned Fear ◽  
Stress Model ◽  
Conditioned Fear Stress

P.1.086 R-citalopram counteracts the effect of escitalopram in a rat conditioned fear stress model of anxiety

2003 ◽  
Vol 13 ◽  
pp. S211
Author(s):  
C. Sánchez ◽  
E. Bien ◽  
P. Gruca
Keyword(s):  
Conditioned Fear ◽  
Stress Model ◽  
Conditioned Fear Stress

Different roles of μ-, δ- and κ-opioid receptors in ethanol-associated place preference in rats exposed to conditioned fear stress

1999 ◽  
Vol 368 (1) ◽  
pp. 9-16 ◽  
Author(s):  
Shigeki Matsuzawa ◽  
Tsutomu Suzuki ◽  
Miwa Misawa ◽  
Hiroshi Nagase
Keyword(s):  
Opioid Receptors ◽  
Conditioned Fear ◽  
Place Preference ◽  
Conditioned Fear Stress

Effects of conditioned fear stress on serotonin neurotransmission and freezing behavior in rats

1999 ◽  
Vol 378 (1) ◽  
pp. 23-30 ◽  
Author(s):  
Shinji Hashimoto ◽  
Takeshi Inoue ◽  
Tsukasa Koyama
Keyword(s):  
Conditioned Fear ◽  
Freezing Behavior ◽  
Conditioned Fear Stress
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