scholarly journals Anlianginal effects of DY-9708. a novel K+ channel opener, in isolated dog coronary artery, anesthetized dogs and anginal models of rats

1995 ◽  
Vol 67 ◽  
pp. 269
Author(s):  
Akira Kanda ◽  
Yoshikalu Amatsu ◽  
Keiko Kinoshita ◽  
Akiko Hiratsuka ◽  
Yoshmori Horada ◽  
...  
1996 ◽  
Vol 270 (6) ◽  
pp. H2210-H2215 ◽  
Author(s):  
Y. Katsuda ◽  
K. Egashira ◽  
H. Ueno ◽  
Y. Arai ◽  
Y. Akatsuka ◽  
...  

The opening of ATP-sensitive K+ (K+ATP) channels contributes to the mechanism of metabolic coronary vasodilation. The aim of the present study was to determine whether K+ATP channel opener pinacidil augments coronary vasodilation induced by beta-adrenoceptor stimulation. In anesthetized dogs, coronary vasodilation in response to intracoronary infusion of a beta 1-adrenoceptor agonist denopamine, selective beta 2-adrenoceptor stimulation with isoproterenol after bisoprolol or nitroglycerin was studied before and during simultaneous intracoronary infusion of pinacidil at a dose of 1 microgram/min, which had no effect on basal hemodynamics. Pinacidil augmented the denopamine-induced increase in coronary blood flow (CBF) from 38 +/- 9 to 66 +/- 16% (P < 0.05) but did not affect the denopamine-induced by isoproterenol or nitroglycerin. Thus pinacidil selectively augmented beta 1-adrenoceptor-mediated coronary vasodilation. These observations suggest that the K+ATP channel opener pinacidil may increase myocardial perfusion during metabolic stress associated with beta 1-adrenoceptor stimulation.


Author(s):  
JosephL. Balwierczak ◽  
ChristineM. Krulan ◽  
HelenS. Kim ◽  
Dominick DelGrande ◽  
GeorgeB. Weiss ◽  
...  

1995 ◽  
Vol 26 (2) ◽  
pp. 189-197 ◽  
Author(s):  
Hideakira Izumi ◽  
Yasuhiro Jinno ◽  
Soichiro Kaneta ◽  
Yoshihiro Tanaka ◽  
Yuji Okada ◽  
...  

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