scholarly journals Anlianginal effects of DY-9708. a novel K+ channel opener, in isolated dog coronary artery, anesthetized dogs and anginal models of rats

1995 ◽  
Vol 67 ◽  
pp. 269
Author(s):  
Akira Kanda ◽  
Yoshikalu Amatsu ◽  
Keiko Kinoshita ◽  
Akiko Hiratsuka ◽  
Yoshmori Horada ◽  
...  
Keyword(s):  
Coronary Artery ◽  
K Channel ◽  
Channel Opener ◽  
Anesthetized Dogs ◽  
K Channel Opener

ATP-sensitive K+ channel opener pinacidil augments beta 1-adrenoceptor-induced coronary vasodilation in dogs

1996 ◽  
Vol 270 (6) ◽  
pp. H2210-H2215 ◽  
Author(s):  
Y. Katsuda ◽  
K. Egashira ◽  
H. Ueno ◽  
Y. Arai ◽  
Y. Akatsuka ◽  
...  
Keyword(s):  
Metabolic Stress ◽  
K Channel ◽  
Coronary Vasodilation ◽  
Beta Adrenoceptor ◽  
Intracoronary Infusion ◽  
Channel Opener ◽  
Adrenoceptor Agonist ◽  
Anesthetized Dogs ◽  
Beta 2 ◽  
K Channel Opener

The opening of ATP-sensitive K+ (K+ATP) channels contributes to the mechanism of metabolic coronary vasodilation. The aim of the present study was to determine whether K+ATP channel opener pinacidil augments coronary vasodilation induced by beta-adrenoceptor stimulation. In anesthetized dogs, coronary vasodilation in response to intracoronary infusion of a beta 1-adrenoceptor agonist denopamine, selective beta 2-adrenoceptor stimulation with isoproterenol after bisoprolol or nitroglycerin was studied before and during simultaneous intracoronary infusion of pinacidil at a dose of 1 microgram/min, which had no effect on basal hemodynamics. Pinacidil augmented the denopamine-induced increase in coronary blood flow (CBF) from 38 +/- 9 to 66 +/- 16% (P < 0.05) but did not affect the denopamine-induced by isoproterenol or nitroglycerin. Thus pinacidil selectively augmented beta 1-adrenoceptor-mediated coronary vasodilation. These observations suggest that the K+ATP channel opener pinacidil may increase myocardial perfusion during metabolic stress associated with beta 1-adrenoceptor stimulation.

Evidence that BKCa channel activation contributes to K+ channel opener induced relaxation of the porcine coronary artery

1995 ◽  
Vol 352 (2) ◽  
Author(s):  
JosephL. Balwierczak ◽  
ChristineM. Krulan ◽  
HelenS. Kim ◽  
Dominick DelGrande ◽  
GeorgeB. Weiss ◽  
...  
Keyword(s):  
Coronary Artery ◽  
K Channel ◽  
Bkca Channel ◽  
Channel Activation ◽  
Porcine Coronary Artery ◽  
Channel Opener ◽  
K Channel Opener

Effects of KRN4884, a Novel K Channel Opener, on the Cardiovascular System in Anesthetized Dogs

1995 ◽  
Vol 26 (2) ◽  
pp. 189-197 ◽  
Author(s):  
Hideakira Izumi ◽  
Yasuhiro Jinno ◽  
Soichiro Kaneta ◽  
Yoshihiro Tanaka ◽  
Yuji Okada ◽  
...  
Keyword(s):  
Cardiovascular System ◽  
K Channel ◽  
Channel Opener ◽  
Anesthetized Dogs ◽  
K Channel Opener
Sign in / Sign up

Export Citation Format

Share Document