N-Benzolamoxicillin and N-3,4-dichlorobenzolamoxicillin were synthesized from amoxicillin by acylation with benzoylchloride and 3,4-dichlorobenzoylchloride respectively. Structure characterization of the amoxicillin derivative compounds were done by UV, IR and 1H-NMR spectroscopy. Both derivative compound has antibacterial antivity against Staphylococcus aureus and Escherichia coli. The activity of N-3,4-dichlorobenzolamoxicillin is more active than N-Benzolamoxicillin.
Structure-function relationship in Escherichia coli translational initiation factors. Characterization of IF-3 by high resolution 1H NMR spectroscopy.
