scholarly journals Developmental regulation of insulin-like growth factor II mRNA in different rat tissues.

1986 ◽  
Vol 261 (28) ◽  
pp. 13144-13150 ◽  
Author(s):  
A L Brown ◽  
D E Graham ◽  
S P Nissley ◽  
D J Hill ◽  
A J Strain ◽  
...  
Keyword(s):  
Growth Factor ◽  
Developmental Regulation ◽  
Rat Tissues ◽  
Insulin Like Growth Factor ◽  
Factor Ii

scholarly journals Coordinate developmental regulation of high and low molecular weight mRNAs for rat insulin-like growth factor II.

1986 ◽  
Vol 83 (12) ◽  
pp. 4519-4523 ◽  
Author(s):  
D. E. Graham ◽  
M. M. Rechler ◽  
A. L. Brown ◽  
R. Frunzio ◽  
J. A. Romanus ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Growth Factor ◽  
Developmental Regulation ◽  
Low Molecular Weight ◽  
Insulin Like Growth Factor ◽  
Factor Ii

Comparison of receptors for insulin-like growth factor II from various rat tissues

1987 ◽  
Vol 115 (1) ◽  
pp. 35-NP ◽  
Author(s):  
J. E. Taylor ◽  
C. D. Scott ◽  
R. C. Baxter
Keyword(s):  
Growth Factor ◽  
Ph Dependence ◽  
Polyacrylamide Gel Electrophoresis ◽  
Sodium Dodecyl ◽  
Subcutaneous Fat ◽  
Cross Reactivity ◽  
Rat Tissues ◽  
Insulin Like Growth Factor ◽  
Major Band ◽  
Factor Ii

ABSTRACT Receptors for insulin-like growth factor II (IGF-II) have been compared in solubilized microsomal membranes from rat lung, brain, kidney, heart, epididymal and subcutaneous fat, ovary, testis and adrenals. Highest binding/μg protein was seen with testicular membranes. Receptors from all tissues showed high affinity for human IGF-II (mean association constant = 65 litres/nmol) and a high degree of specificity (mean IGF-I cross-reactivity 0·3%; no cross-reactivity with insulin). Affinity labelling followed by sodium dodecyl sulphate polyacrylamide gel electrophoresis showed binding was only to a type-II IGF receptor, with a major band seen at a molecular weight of about 230 000 in lung, brain, kidney and testis, and 240 000 in heart, fat and adrenal gland. All tissues showed broad or bimodal pH dependence of binding, with optima seen at about pH 6 and pH 9. Mild stimulation of IGF-II binding by low calcium concentrations (1–2 mmol/l) was seen in all tissues, although higher concentrations were inhibitory in the brain. It was concluded that IGF-II receptors from different rat tissues, when studied under uniform conditions, show similar binding affinities but differences in size and regulation which might be missed if receptors are examined in separate studies. J. Endocr. (1987) 115, 35–41

Isolation of an insulin-like growth factor II cDNA from guinea pig liver: Expression and developmental regulation

1992 ◽  
Vol 89 (1-2) ◽  
pp. 105-110 ◽  
Author(s):  
Agneta Levinovitz ◽  
Gunnar Norstedt ◽  
Susanne van den Berg ◽  
Iain C.A.F. Robinson ◽  
Tomas J. Ekström
Keyword(s):  
Growth Factor ◽  
Guinea Pig ◽  
Developmental Regulation ◽  
Insulin Like Growth Factor ◽  
Pig Liver ◽  
Factor Ii ◽  
Guinea Pig Liver

Distribution of Insulin-Like Growth Factor II Receptor Immunoreactivity in Rat Tissues*

Endocrinology ◽  
1988 ◽  
Vol 122 (6) ◽  
pp. 2753-2763 ◽  
Author(s):  
K. L. VALENTINO ◽  
H. PHAM ◽  
I. OCRANT ◽  
R. G. ROSENFELD
Keyword(s):  
Growth Factor ◽  
Rat Tissues ◽  
Insulin Like Growth Factor ◽  
Factor Ii
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