Bio-compatible in-tube solid-phase microextraction capillary for the direct extraction and high-performance liquid chromatographic determination of drugs in human serum

2002 ◽  
Vol 963 (1-2) ◽  
pp. 325-334 ◽  
Author(s):  
Wayne M Mullett ◽  
Karsten Levsen ◽  
Dieter Lubda ◽  
Janusz Pawliszyn
Keyword(s):  
Human Serum ◽  
Solid Phase Microextraction ◽  
High Performance ◽  
Solid Phase ◽  
Chromatographic Determination ◽  
High Performance Liquid Chromatographic ◽  
Direct Extraction ◽  
Liquid Chromatographic Determination ◽  
Liquid Chromatographic

scholarly journals High-performance liquid chromatographic determination of famotidine in human plasma using solid-phase column extraction

2003 ◽  
Vol 68 (11) ◽  
pp. 883-892 ◽  
Author(s):  
Dragica Zendelovska ◽  
Trajce Stafilov
Keyword(s):  
Human Plasma ◽  
High Performance ◽  
Solid Phase ◽  
Internal Standard ◽  
Chromatographic Determination ◽  
High Performance Liquid Chromatographic ◽  
Water Ph ◽  
Liquid Chromatographic Determination ◽  
Liquid Chromatographic

A rapid, specific and sensitive high-performance liquid chromatographic method for the determination of famotidine in human plasma has been developed. Famotidine and the internal standard were chromatographically separated from plasma components using a Lichrocart Lichrospher 60 RP select B cartridge for solid-phase separation with a mobile phase composed of 0.1 % (v/v) triethylamine in water (pH 3) and acetonitrile (92:8, v/v). UV detection was set at 270 nm. The calibration curve was linear in the concentration range of 10.0 ? 350.0 ng mL-1. The method was implemented to monitor the famotidine levels in patient samples.

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