5-Hydroxytryptamine inhibits the tachycardia induced by selective preganglionic sympathetic stimulation in pithed rats

Life Sciences ◽  
1999 ◽  
Vol 64 (20) ◽  
pp. 1839-1847 ◽  
Author(s):  
Carlos M. Villalón ◽  
David Centurión ◽  
María del Mar Fernández ◽  
Asuncion Morán ◽  
Araceli Sánchez-López
Keyword(s):  
Sympathetic Stimulation ◽  
Pithed Rats

Pharmacological profile of 5-hydroxytryptamine-induced inhibition on the pressor effect elicited by sympathetic stimulation in long-term diabetic pithed rats

2010 ◽  
Vol 643 (1) ◽  
pp. 70-77 ◽  
Author(s):  
Asunción Morán ◽  
Beatriz Restrepo ◽  
Ana Vega. Ortiz de Urbina ◽  
Mónica García ◽  
Maria Luisa Martín ◽  
...  
Keyword(s):  
Pressor Effect ◽  
Sympathetic Stimulation ◽  
Pharmacological Profile ◽  
Pithed Rats

Analysis of anandamide- and lysophosphatidylinositol-induced inhibition of the vasopressor responses produced by sympathetic stimulation or noradrenaline in pithed rats

2013 ◽  
Vol 721 (1-3) ◽  
pp. 168-177 ◽  
Author(s):  
Bruno A. Marichal-Cancino ◽  
Guadalupe Manrique-Maldonado ◽  
Alain H. Altamirano-Espinoza ◽  
Inna Ruiz-Salinas ◽  
Abimael González-Hernández ◽  
...  
Keyword(s):  
Sympathetic Stimulation ◽  
Pithed Rats

The nitric oxide synthesis/pathway mediates the inhibitory serotoninergic responses of the pressor effect elicited by sympathetic stimulation in diabetic pithed rats

2006 ◽  
Vol 537 (1-3) ◽  
pp. 126-134 ◽  
Author(s):  
Mónica García ◽  
Asunción Morán ◽  
María Luisa Martín ◽  
Mariette Barthelmebs ◽  
Luis San Román
Keyword(s):  
Nitric Oxide ◽  
Pressor Effect ◽  
Sympathetic Stimulation ◽  
Nitric Oxide Synthesis ◽  
Pithed Rats

Plasma catecholamine and blood pressure responses to sympathetic stimulation in pithed rats

1979 ◽  
Vol 237 (3) ◽  
pp. H305-H310 ◽  
Author(s):  
I. Yamaguchi ◽  
I. J. Kopin
Keyword(s):  
Blood Pressure ◽  
Plasma Levels ◽  
Initial Phase ◽  
Minor Role ◽  
Plasma Norepinephrine ◽  
Plasma Catecholamine ◽  
Sympathetic Stimulation ◽  
Pithed Rats ◽  
Blood Pressure Responses ◽  
A Minor

Sympathetic stimulation in pithed rats elicits increases in blood pressure (BP) and plasma levels of catecholamines. The BP is proportional to the logarithm of the plasma norepinephrine (NE) concentration. Adrenal medullectomy diminishes slightly only the initial phase of the BP responses, whereas bretylium blocks completely the BP response and diminishes by about 70% the increase in plasma NE. Adrenal medullectomy completely prevents the increase in plasma epinephrine (Epi) and diminishes by 30% plasma NE. Plasma levels of NE appear to reflect sympathetic neuronal activity, but the NE at sympathetic nerve endings is responsible for the increase in BP. Epi released from the adrenal medulla may enhance and accelerate the initial BP response, but plays only a minor role after the first 15 s.

A Specific Increase in Cardiovascular Reactivity Related to Sodium Retention in Doca-Salt-Treated Rats

1973 ◽  
Vol 45 (5) ◽  
pp. 571-581 ◽  
Author(s):  
G. J. Dusting ◽  
M. J. Rand ◽  
G. S. Harris
Keyword(s):  
Heart Rate ◽  
Whole Body ◽  
Sodium Retention ◽  
Sympathetic Stimulation ◽  
Vascular Responses ◽  
Body Sodium ◽  
Pressor Responses ◽  
Pithed Rats ◽  
Specific Increase ◽  
The Difference

1. Exchangeable body sodium was measured in deoxycorticosterone acetate (DOCA) -salt-treated rats by whole body γ-counting after equilibration with a 22Na isotope. 2. The blood pressure of DOCA-salt-treated rats is positively correlated with their exchangeable body sodium. 3. After pithing, the heart rate is significantly lower in DOCA-salt-treated than in control rats: in conscious DOCA-salt-treated rats the heart rate is also lower than in control rats but the difference was not statistically significant. 4. Cardiac and vascular responses to sympathetic stimulation are positively correlated with exchangeable body sodium in pithed rats, but there is no correlation between either cardiac or vascular responses to noradrenaline injections and exchangeable sodium. 5. Pressor responses to sympathetic stimulation in pithed DOCA-salt-treated rats are potentiated less by cocaine than are responses of untreated control rats. 6. It is suggested that sodium retention in mildly hypertensive rats specifically enhances responses to sympathetic stimulation by increasing the availability of the sympathetic transmitter.

Sign in / Sign up

Export Citation Format

Share Document