Synthesis of the water-soluble adenosine A1 receptor antagonist FR166124 through a novel sequential Horner-Emmons / isomerization reaction

Tetrahedron ◽  
1999 ◽  
Vol 55 (34) ◽  
pp. 10351-10364 ◽  
Author(s):  
Satoru Kuroda ◽  
Atsushi Akahane ◽  
Hiromichi Itani ◽  
Shintaro Nishimura ◽  
Kieran Durkin ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Water Soluble ◽  
Adenosine A1 Receptor ◽  
Isomerization Reaction ◽  
Adenosine A1 ◽  
A1 Receptor

ChemInform Abstract: Discovery of FR166124, a Novel Water-Soluble Pyrazolo[1,5-a]pyridine Adenosine A1 Receptor Antagonist.

ChemInform ◽  
2010 ◽  
Vol 30 (43) ◽  
pp. no-no
Author(s):  
Satoru Kuroda ◽  
Atsushi Akahane ◽  
Hiromichi Itani ◽  
Shintaro Nishimura ◽  
Kieran Durkin ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Water Soluble ◽  
Adenosine A1 Receptor ◽  
Adenosine A1 ◽  
A1 Receptor

Discovery of FR166124, a novel water-soluble pyrazolo-[1,5-α]pyridine adenosine A1 receptor antagonist

1999 ◽  
Vol 9 (14) ◽  
pp. 1979-1984 ◽  
Author(s):  
Satoru Kuroda ◽  
Atsushi Akahane ◽  
Hiromichi Itani ◽  
Shintaro Nishimura ◽  
Kieran Durkin ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Water Soluble ◽  
Adenosine A1 Receptor ◽  
Adenosine A1 ◽  
A1 Receptor

Discovery of FK453, a novel non-xanthine adenosine A1 receptor antagonist

1996 ◽  
Vol 6 (17) ◽  
pp. 2059-2062 ◽  
Author(s):  
Atsushi Akahane ◽  
Hirohito Katayama ◽  
Takafumi Mitsunaga ◽  
Yasuhiro Kita ◽  
Takahiro Kusunoki ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Adenosine A1 Receptor ◽  
Adenosine A1 ◽  
A1 Receptor
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