Tumor suppression activity of adenovirus e1a protein: Anoikis and the epithelial phenotype

2001 ◽  
pp. 39-49 ◽  
Author(s):  
Steven M. Frisch
Keyword(s):  
Tumor Suppression ◽  
Adenovirus E1a ◽  
Epithelial Phenotype ◽  
E1a Protein

scholarly journals Induction of transcription factor AP-1 by adenovirus E1A protein and cAMP.

1989 ◽  
Vol 3 (12a) ◽  
pp. 1991-2002 ◽  
Author(s):  
U Muller ◽  
M P Roberts ◽  
D A Engel ◽  
W Doerfler ◽  
T Shenk
Keyword(s):  
Transcription Factor ◽  
Adenovirus E1a ◽  
E1a Protein

scholarly journals Cells differentiating into neuroectoderm undergo apoptosis in the absence of functional retinoblastoma family proteins.

1995 ◽  
Vol 129 (3) ◽  
pp. 779-788 ◽  
Author(s):  
R S Slack ◽  
I S Skerjanc ◽  
B Lach ◽  
J Craig ◽  
K Jardine ◽  
...  
Keyword(s):  
Cell Death ◽  
P19 Cells ◽  
Adenovirus E1a ◽  
Genes Encoding ◽  
Extensive Cell Death ◽  
Extensive Cell ◽  
Early Mouse ◽  
Dying Cells ◽  
Related Proteins ◽  
E1a Protein

The retinoblastoma (RB) protein is present at low levels in early mouse embryos and in pluripotent P19 embryonal carcinoma cells; however, the levels of RB rise dramatically in neuroectoderm formed both in embryos and in differentiating cultures of P19 cells. To investigate the effect of inactivating RB and related proteins p107 and p130, we transfected P19 cells with genes encoding mutated versions of the adenovirus E1A protein that bind RB and related proteins. When these E1A-expressing P19 cells were induced to differentiate into neuroectoderm, there was a striking rise in the expression of c-fos and extensive cell death. The ultrastructural and biochemical characteristics of the dying cells were indicative of apoptosis. The dying cells were those committed to the neural lineages because neurons and astrocytes were lost from differentiating cultures. Cell death was dependent on the ability of the E1A protein to bind RB and related proteins. Our results suggest that proteins of the RB family are essential for the development of the neural lineages and that the absence of functional RB activity triggers apoptosis of differentiating neuroectodermal cells.

scholarly journals Direct interaction between adenovirus E1A protein and the TATA box binding transcription factor IID.

1991 ◽  
Vol 88 (12) ◽  
pp. 5124-5128 ◽  
Author(s):  
N. Horikoshi ◽  
K. Maguire ◽  
A. Kralli ◽  
E. Maldonado ◽  
D. Reinberg ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Direct Interaction ◽  
Tata Box ◽  
Adenovirus E1a ◽  
Transcription Factor Iid ◽  
E1a Protein

Transcription activation by the adenovirus E1a protein

Nature ◽  
1989 ◽  
Vol 338 (6210) ◽  
pp. 39-44 ◽  
Author(s):  
James W. Lillie ◽  
Michael R. Green
Keyword(s):  
Transcription Activation ◽  
Adenovirus E1a ◽  
E1a Protein

scholarly journals The Adenovirus E1A Protein Is a Potent Coactivator for Thyroid Hormone Receptors

1999 ◽  
Vol 13 (7) ◽  
pp. 1119-1129 ◽  
Author(s):  
Gunilla M. Wahlström ◽  
Björn Vennström ◽  
Maria Bondesson Bolin
Keyword(s):  
Thyroid Hormone ◽  
Hormone Receptors ◽  
Thyroid Hormone Receptors ◽  
Adenovirus E1a ◽  
E1a Protein

Activation of transcription factor IIIC by the adenovirus E1A protein

Cell ◽  
1988 ◽  
Vol 53 (6) ◽  
pp. 907-920 ◽  
Author(s):  
Warren K. Hoeffler ◽  
Robert Kovelman ◽  
Robert G. Roeder
Keyword(s):  
Transcription Factor ◽  
Adenovirus E1a ◽  
Activation Of Transcription ◽  
E1a Protein

scholarly journals The adenovirus E1A protein overrides the requirement for cellular ras in initiating DNA synthesis.

1994 ◽  
Vol 13 (24) ◽  
pp. 6107-6114 ◽  
Author(s):  
D.W. Stacey ◽  
S.F. Dobrowolski ◽  
A. Piotrkowski ◽  
M.L. Harter
Keyword(s):  
Dna Synthesis ◽  
Adenovirus E1a ◽  
E1a Protein
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