Relationship of Serum Digoxin Concentration to Mortality and Morbidity in Women in the Digitalis Investigation Group Trial: A Retrospective Analysis

2006 ◽  
Vol 2006 ◽  
pp. 346-348
Author(s):  
W.H. Frishman
Keyword(s):  
Retrospective Analysis ◽  
Digoxin Concentration ◽  
Serum Digoxin Concentration ◽  
Mortality And Morbidity ◽  
Serum Digoxin ◽  
Relationship Of ◽  
Group Trial

scholarly journals Relationship of Serum Digoxin Concentration to Mortality and Morbidity in Women in the Digitalis Investigation Group Trial

2005 ◽  
Vol 46 (3) ◽  
pp. 497-504 ◽  
Author(s):  
Kirkwood F. Adams ◽  
J. Herbert Patterson ◽  
Wendy A. Gattis ◽  
Christopher M. O’Connor ◽  
Craig R. Lee ◽  
...  
Keyword(s):  
Digoxin Concentration ◽  
Serum Digoxin Concentration ◽  
Mortality And Morbidity ◽  
Serum Digoxin ◽  
Relationship Of ◽  
Group Trial

Dose response characterization of the association of serum digoxin concentration with mortality outcomes in the Digitalis Investigation Group trial

2016 ◽  
Vol 18 (8) ◽  
pp. 1072-1081 ◽  
Author(s):  
Kirkwood F. Adams ◽  
Javed Butler ◽  
J. Herbert Patterson ◽  
Wendy Gattis Stough ◽  
Jerry L. Bauman ◽  
...  
Keyword(s):  
Dose Response ◽  
Digoxin Concentration ◽  
Serum Digoxin Concentration ◽  
Serum Digoxin ◽  
Group Trial

Therapeutic Serum Digoxin Concentration: Relation to Age, Weight, Sex, and Serum Creatinine Levels‡‡

1973 ◽  
Vol 3 (6) ◽  
pp. 606-613 ◽  
Author(s):  
G. J. Schapel ◽  
B. P. McGrath ◽  
K. D. G. Edwards ◽  
M. R. Hawkins ◽  
A. S. Mitchell
Keyword(s):  
Serum Creatinine ◽  
Digoxin Concentration ◽  
Serum Digoxin Concentration ◽  
Serum Digoxin

Digoxin Toxicity Secondary to Clarithromycin Therapy

1997 ◽  
Vol 31 (7-8) ◽  
pp. 864-866 ◽  
Author(s):  
James J. Nawarskas ◽  
David M. McCarthy ◽  
Sarah A. Spinier
Keyword(s):  
Digoxin Concentration ◽  
Serum Digoxin Concentration ◽  
Digoxin Toxicity ◽  
Case Summary ◽  
Serum Digoxin ◽  
St Segment ◽  
Digoxin Bioavailability ◽  
Electrocardiogram Ecg ◽  
Ecg Abnormalities ◽  
Digoxin Therapy

OBJECTIVE: To report a case of digoxin toxicity thought to be secondary to clarithromycin therapy. CASE SUMMARY: A 78-year-old white woman with congestive heart failure taking digoxin 0.25 mg po qd presented to our hospital with nausea, vomiting, and diarrhea. She had taken clarithromycin 500 mg po bid for 3 days, and a serum digoxin concentration obtained the day of admission was 4.4 μg/L. An electrocardiogram (ECG) done on admission revealed ST segment changes consistent with digoxin effect and later asymptomatic, nonsustained ventricular tachycardia (NSVT). Clarithromycin was discontinued and digoxin was withheld at admission, resulting in the resolution of symptoms, ECG abnormalities, and NSVT on day 3 of hospitalization. On day 5 her serum digoxin concentration was 1.5 μg/L and digoxin therapy was reinstituted at a dose of 0.125 mg/d po. DISCUSSION: This is the fourth published case implicating clarithromycin as the cause of digoxin toxicity. This interaction is most likely due to clarithromycin eradication of digoxinmetabolizing gut flora, thereby increasing digoxin bioavailability. CONCLUSIONS: Approximately 10% of patients are thought to be extensive presystemic metabolizers of digoxin and may therefore be most susceptible to a drug interaction with clarithromycin. Serum digoxin concentrations in such patients should be monitored closely during clarithromycin therapy.

Sign in / Sign up

Export Citation Format

Share Document