scholarly journals Effects of X-Rays on Nucleic Acid Biosynthesis and on the Activity of Nucleases in Mammalian Cells

1961 ◽  
Vol 11 ◽  
pp. 53-77 ◽  
Author(s):  
R. Goutier
Keyword(s):  
Nucleic Acid ◽  
Mammalian Cells ◽  
X Rays ◽  
Acid Biosynthesis ◽  
Nucleic Acid Biosynthesis

scholarly journals Antitrypanosomal Activities of Fluoroquinolones with Pyrrolidinyl Substitutions

2003 ◽  
Vol 47 (9) ◽  
pp. 3015-3017 ◽  
Author(s):  
Elizabeth Nenortas ◽  
Tomasz Kulikowicz ◽  
Christian Burri ◽  
Theresa A. Shapiro
Keyword(s):  
Nucleic Acid ◽  
Trypanosoma Brucei ◽  
Mammalian Cells ◽  
Topoisomerase Ii ◽  
Acid Biosynthesis ◽  
Selective Toxicity ◽  
Dna Complexes ◽  
Antitrypanosomal Activity ◽  
Nucleic Acid Biosynthesis ◽  
Thiazolidine Ring

ABSTRACT Fluoroquinolones with pyrrolidinyl substitutions were tested against Trypanosoma brucei and mammalian cells. Bulky substituents at C-7 or a 1-2-bridging thiazolidine ring increased antitrypanosomal activity and selective toxicity. These compounds trap protein-DNA complexes and inhibit nucleic acid biosynthesis in trypanosomes, characteristics of topoisomerase II inhibition.

Computer study of the role of hydration in the accuracy of nucleic acid biosynthesis

1999 ◽  
Vol 493 (1-3) ◽  
pp. 301-308 ◽  
Author(s):  
E. Gonzalez-Jiménez ◽  
I. Castro-Valdez ◽  
E. López-Apresa ◽  
S.V. Filippov ◽  
A.V. Teplukhin ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Computer Study ◽  
Acid Biosynthesis ◽  
Nucleic Acid Biosynthesis

Restoration of nucleic acid biosynthesis after clinical death and factors stimulating the process in vivo

Resuscitation ◽  
1975 ◽  
Vol 4 (2) ◽  
pp. 125-130 ◽  
Author(s):  
Anna S. Konikova ◽  
Ludmila M. Petukhova ◽  
Antonina V. Pogossova ◽  
Anna A. Vinarskaya ◽  
V.I. Nikulin
Keyword(s):  
Nucleic Acid ◽  
Clinical Death ◽  
Acid Biosynthesis ◽  
Nucleic Acid Biosynthesis
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