Recovery of second mandibular molar after collapse in space made by early extraction of first molar bringing second molar into position occupied by first molar and making room for impacted third molar

Author(s):  
William C. Fisher
2011 ◽  
Vol 90 (11) ◽  
pp. 1312-1317 ◽  
Author(s):  
X.L. Han ◽  
M. Liu ◽  
A. Voisey ◽  
Y.S. Ren ◽  
P. Kurimoto ◽  
...  

Dickkopf-related protein 1 (DKK1) is a potent inhibitor of Wnt/β-catenin signaling. Dkk1-null mutant embryos display severe defects in head induction. Conversely, targeted expression of Dkk1 in dental epithelial cells leads to the formation of dysfunctional enamel knots and subsequent tooth defects during embryonic development. However, its role in post-natal dentinogenesis is largely unknown. To address this issue, we studied the role of DKK1 in post-natal dentin development using 2.3-kb Col1a1- Dkk1 transgenic mice, with the following key findings: (1) The Dkk1 transgene was highly expressed in pulp and odontoblast cells during post-natal developmental stages; (2) the 1st molar displayed short roots, an enlarged pulp/root canal region, and a decrease in the dentin formation rate; (3) a small malformed second molar and an absent third molar; (4) an increase of immature odontoblasts, few mature odontoblasts, and sharply reduced dentinal tubules; and (5) a dramatic change in Osx and nestin expression. We propose that DKK1 controls post-natal mandibular molar dentin formation either directly or indirectly via the inhibition of Wnt signaling at the following aspects: (i) post-natal dentin formation, (ii) formation and/or maintenance of the dentin tubular system, (iii) mineralization of the dentin, and (iv) regulation of molecules such as Osx and nestin.


Author(s):  
Majid Fereidooni ◽  
Oveis Khakbaz ◽  
Najme Danesh Alukande ◽  
Soraya Khafri ◽  
◽  
...  

2021 ◽  
Vol 10 (02) ◽  
pp. 116-119
Author(s):  
Chandrashekhar Pandey ◽  
Bishwa Prakash Bhattarai ◽  
Manop Khanijou ◽  
Pimolmas Na Songkla ◽  
Natthamet Wongsirichat ◽  
...  

AbstractThere have been infrequent case reports of bilateral root resorption in the lower second molar secondary from impacted third molar removal with bone regeneration without pain. Root resorption is commonly observed during third molar surgical impaction that affects mandibular second molars. The bone regeneration into the adjacent affected tooth is evident simply after the surgical extraction of the impacted tooth. However, there have been a few previous reports on the prognosis of the remaining resorbed tooth. Most dentists often choose to extract them when damaged if root resorption is observed. This report case involved bilateral root resorption of the lower second molar due to lower adjacent impacted third molar teeth and bone regeneration without pain sensation. After surgical extraction of bilateral lower impacted third molar teeth, the remaining teeth retained vital pulp and survived as functional teeth.


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