OC-0153 EGFR-INHIBITION AND RADIOTHERAPY IN HEAD AND NECK CANCER XENOGRAFTS: HYPOXIA, PROLIFERATION AND TUMOR GROWTH DELAY

2012 ◽  
Vol 103 ◽  
pp. S59
Author(s):  
H. Stegeman ◽  
J.H.A.M. Kaanders ◽  
A.J. van der Kogel ◽  
M. Iida ◽  
D.L. Wheeler ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Tumor Growth ◽  
Head And Neck ◽  
Neck Cancer ◽  
Growth Delay ◽  
Tumor Growth Delay ◽  
Egfr Inhibition

Abstract 4243: EGFR inhibition causes growth delay and induces apoptosis in HPV-positive head and neck cancer

2014 ◽  
Author(s):  
Alexandra D. Torres Law ◽  
Grace C. Blitzer ◽  
Molly A. Smith ◽  
Eric A. Armstrong ◽  
Randall J. Kimple
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Growth Delay ◽  
Egfr Inhibition

Reirradiation plus EGFR inhibition in locally recurrent and unresectable head and neck cancer

2013 ◽  
Vol 189 (10) ◽  
pp. 842-848 ◽  
Author(s):  
D. Milanović ◽  
B. Jeremić ◽  
A.L. Grosu ◽  
G. Rücker ◽  
M. Henke
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Egfr Inhibition ◽  
Locally Recurrent

scholarly journals Carfilzomib and ONX 0912 Inhibit Cell Survival and Tumor Growth of Head and Neck Cancer and Their Activities Are Enhanced by Suppression of Mcl-1 or Autophagy

2012 ◽  
Vol 18 (20) ◽  
pp. 5639-5649 ◽  
Author(s):  
Yan Zang ◽  
Sufi M. Thomas ◽  
Elena T. Chan ◽  
Christopher J. Kirk ◽  
Maria L. Freilino ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Tumor Growth ◽  
Cell Survival ◽  
Head And Neck ◽  
Neck Cancer

scholarly journals Lyn Kinase Mediates Cell Motility and Tumor Growth in EGFRvIII-Expressing Head and Neck Cancer

2012 ◽  
Vol 18 (10) ◽  
pp. 2850-2860 ◽  
Author(s):  
Sarah E. Wheeler ◽  
Elena M. Morariu ◽  
Joseph S. Bednash ◽  
Charlton G. Otte ◽  
Raja R. Seethala ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Tumor Growth ◽  
Cell Motility ◽  
Head And Neck ◽  
Neck Cancer ◽  
Lyn Kinase

61 EFFECTS OF EGFR-INHIBITION AND RADIOTHERAPY ON HYPOXIA, PROLIFERATION AND TUMOR GROWTH DELAY IN HUMAN TUMOR XENOGRAFTS

2012 ◽  
Vol 102 ◽  
pp. S21
Author(s):  
H. Stegeman ◽  
P. Span ◽  
A.J. van der Kogel ◽  
D. Wheeler ◽  
J. Kaanders ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Human Tumor ◽  
Growth Delay ◽  
Tumor Growth Delay ◽  
Human Tumor Xenografts ◽  
Tumor Xenografts ◽  
Egfr Inhibition

VISUALIZATION OF HEAD AND NECK CANCER MODELS WITH A TRIPLE FUSION REPORTER GENE

2012 ◽  
Vol 05 (04) ◽  
pp. 1250028 ◽  
Author(s):  
YING ZHENG ◽  
QIAOYA LIN ◽  
HONGLIN JIN ◽  
JUAN CHEN ◽  
ZHIHONG ZHANG
Keyword(s):  
Head And Neck Cancer ◽  
Animal Models ◽  
Tumor Growth ◽  
Head And Neck ◽  
Reporter Gene ◽  
Neck Cancer ◽  
Bioluminescence Imaging ◽  
Head And Neck Tumors ◽  
Neck Tumors

The development of experimental animal models for head and neck tumors generally rely on the bioluminescence imaging to achieve the dynamic monitoring of the tumor growth and metastasis due to the complicated anatomical structures. Since the bioluminescence imaging is largely affected by the intracellular luciferase expression level and external D-luciferin concentrations, its imaging accuracy requires further confirmation. Here, a new triple fusion reporter gene, which consists of a herpes simplex virus type 1 thymidine kinase (TK) gene for radioactive imaging, a far-red fluorescent protein (mLumin) gene for fluorescent imaging, and a firefly luciferase gene for bioluminescence imaging, was introduced for in vivo observation of the head and neck tumors through multi-modality imaging. Results show that fluorescence and bioluminescence signals from mLumin and luciferase, respectively, were clearly observed in tumor cells, and TK could activate suicide pathway of the cells in the presence of nucleotide analog-ganciclovir (GCV), demonstrating the effectiveness of individual functions of each gene. Moreover, subcutaneous and metastasis animal models for head and neck tumors using the fusion reporter gene-expressing cell lines were established, allowing multi-modality imaging in vivo. Together, the established tumor models of head and neck cancer based on the newly developed triple fusion reporter gene are ideal for monitoring tumor growth, assessing the drug therapeutic efficacy and verifying the effectiveness of new treatments.

Adenovirus-mediated expression of dominant negative c-myb induces apoptosis in head and neck cancer cells and inhibits tumor growth in animal model

Oral Oncology ◽  
2008 ◽  
Vol 44 (4) ◽  
pp. 383-392 ◽  
Author(s):  
Sun Young Kim ◽  
Yun Soo Yang ◽  
Ki Hwang Hong ◽  
Kyu Yun Jang ◽  
Myoung Ja Chung ◽  
...  
Keyword(s):  
Animal Model ◽  
Head And Neck Cancer ◽  
Tumor Growth ◽  
Head And Neck ◽  
Cancer Cells ◽  
Neck Cancer ◽  
Dominant Negative
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