PO-1242: Early radiotherapy and high-dose chemotherapy improve survival of atypical teratoid rhabdoid tumors

2020 ◽  
Vol 152 ◽  
pp. S654
Author(s):  
W.C. Yang ◽  
Y. Hu ◽  
Y. Chen
Keyword(s):  
High Dose Chemotherapy ◽  
High Dose ◽  
Atypical Teratoid ◽  
Atypical Teratoid Rhabdoid Tumors ◽  
Rhabdoid Tumors

scholarly journals Atypical teratoid-rhabdoid tumors: molecular genetics feutures, perspectives of treatment. Review of literature

2020 ◽  
Vol 7 (1) ◽  
pp. 41-50
Author(s):  
A. Yu. Smirnova ◽  
A. Yu. Goncharov ◽  
Yu. V. Dinikina ◽  
A. V. Kim ◽  
W. A. Khachatryan ◽  
...  
Keyword(s):  
High Dose Chemotherapy ◽  
Monogenic Disease ◽  
Molecular Characteristics ◽  
Intrathecal Therapy ◽  
High Dose ◽  
Biallelic Mutation ◽  
Conventional Dose ◽  
Atypical Teratoid ◽  
Atypical Teratoid Rhabdoid Tumors ◽  
Rhabdoid Tumors

Atypical teratoid rhabdoid tumors (ATRT) are the most common malignant embryonal tumors of central nervous system in young children. Metastatic stage reveals in 20–30 % cases at the diagnosis. ATRT is a primarily monogenic disease characterized by the biallelic mutation of the SMARCB1, more rarely SMARCA4 genes. The survival rate of ATRT’s patients is poor. Multimodal treatment approaches including surgery, conventional dose chemotherapy with intrathecal therapy, high-dose chemotherapy with autologous stem cell resсue and radiotherapy have shown significant potential for improving outcomes. Recent epigenetic and transcriptional studies conducted by two independent research groups have identified three subgroups of ATRT. It has different molecular characteristics with appropriate therapeutic sensitivity. Further study of molecular types, inclusion of biologically targeted agents may be a promising strategy for optimizing treatment in future studies.

Atypical Teratoid or Rhabdoid Tumors: Improved Outcome With High-dose Chemotherapy

2010 ◽  
Vol 32 (5) ◽  
pp. e182-e186 ◽  
Author(s):  
Tal Finkelstein-Shechter ◽  
Adam Gassas ◽  
Donald Mabbott ◽  
Annie Huang ◽  
Ute Bartels ◽  
...  
Keyword(s):  
High Dose Chemotherapy ◽  
High Dose ◽  
Atypical Teratoid ◽  
Rhabdoid Tumors ◽  
Improved Outcome

scholarly journals Preclinical high-dose acetaminophen with N -acetylcysteine rescue enhances the efficacy of cisplatin chemotherapy in atypical teratoid rhabdoid tumors

2013 ◽  
Vol 61 (1) ◽  
pp. 120-127 ◽  
Author(s):  
Alexander J. Neuwelt ◽  
Tam Nguyen ◽  
Y. Jeffrey Wu ◽  
Andrew M. Donson ◽  
Rajeev Vibhakar ◽  
...  
Keyword(s):  
High Dose ◽  
Atypical Teratoid ◽  
Atypical Teratoid Rhabdoid Tumors ◽  
Rhabdoid Tumors
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