939 PRECLINICAL PHARMACOKINETIC AND ADME CHARACTERIZATION OF VCH-222, A NOVEL NON-NUCLEOSIDE HCV NS5B POLYMERASE INHIBITOR

Polymerase Inhibitor ◽

Hcv Ns5b ◽

Characterization of forced degradation products and in silico toxicity prediction of Sofosbuvir: A novel HCV NS5B polymerase inhibitor

Journal of Pharmaceutical and Biomedical Analysis ◽

10.1016/j.jpba.2015.12.045 ◽

2016 ◽

Vol 120 ◽

pp. 352-363 ◽

Cited By ~ 22

Author(s):

Debasish Swain ◽

Gananadhamu Samanthula ◽

Shweta Bhagat ◽

P.V. Bharatam ◽

Venkatakrishna Akula ◽

...

Keyword(s):

In Silico ◽

Degradation Products ◽

Forced Degradation ◽

Toxicity Prediction ◽

In Silico Toxicity ◽

Polymerase Inhibitor ◽

Hcv Ns5b ◽

845 PRECLINICAL PHARMACOKINETIC AND ADME CHARACTERIZATION OF VCH-916, A NOVEL NON-NUCLEOSIDE HCV NS5B POLYMERASE INHIBITOR

Journal of Hepatology ◽

10.1016/s0168-8278(08)60847-8 ◽

2008 ◽

Vol 48 ◽

pp. S317 ◽

Cited By ~ 1

Author(s):

N. Chauret ◽

C. Chagnon-Labelle ◽

M. Diallo ◽

J. Laquerre ◽

S. Plante

Keyword(s):

Polymerase Inhibitor ◽

Hcv Ns5b ◽

The First Kilogram Synthesis of Beclabuvir, an HCV NS5B Polymerase Inhibitor

Organic Process Research & Development ◽

10.1021/acs.oprd.8b00214 ◽

2018 ◽

Vol 22 (10) ◽

pp. 1393-1408 ◽

Cited By ~ 9

Author(s):

Jeffrey Bien ◽

Akin Davulcu ◽

Albert J. DelMonte ◽

Kenneth J. Fraunhoffer ◽

Zhinong Gao ◽

...

Keyword(s):

Polymerase Inhibitor ◽

Hcv Ns5b ◽

P0688 : Preclinical characterisation of MIV-802, a novel uridine nucleotide HCV NS5B polymerase inhibitor, for treatment of hepatitis C virus infection

Journal of Hepatology ◽

10.1016/s0168-8278(15)30891-6 ◽

2015 ◽

Vol 62 ◽

pp. S580 ◽

Cited By ~ 1

Author(s):

A. Lindqvist ◽

H. Kylefjord ◽

H. Wähling ◽

S. Juric ◽

S. Torssell ◽

...

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Virus Infection ◽

Hepatitis C Virus Infection ◽

Uridine Nucleotide ◽

Polymerase Inhibitor ◽

Hcv Ns5b ◽

Synthesis and Anti-HCV Activity of Sugar-Modified Guanosine Analogues: Discovery of AL-611 as an HCV NS5B Polymerase Inhibitor for the Treatment of Chronic Hepatitis C

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.0c00935 ◽

2020 ◽

Vol 63 (18) ◽

pp. 10380-10395 ◽

Cited By ~ 1

Author(s):

Guangyi Wang ◽

Natalia Dyatkina ◽

Marija Prhavc ◽

Caroline Williams ◽

Vladimir Serebryany ◽

...

Keyword(s):

Chronic Hepatitis ◽

Hepatitis C ◽

Chronic Hepatitis C ◽

Polymerase Inhibitor ◽

Hcv Ns5b ◽

Multi-parameter optimization of aza-follow-ups to BI 207524, a thumb pocket 1 HCV NS5B polymerase inhibitor. Part 2: Impact of lipophilicity on promiscuity and in vivo toxicity

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2014.12.078 ◽

2015 ◽

Vol 25 (5) ◽

pp. 1140-1145 ◽

Cited By ~ 5

Author(s):

Pierre L. Beaulieu ◽

Gordon Bolger ◽

Dan Deon ◽

Martin Duplessis ◽

Gulrez Fazal ◽

...

Keyword(s):

Parameter Optimization ◽

In Vivo Toxicity ◽

Polymerase Inhibitor ◽

Hcv Ns5b ◽

Discovery of an irreversible HCV NS5B polymerase inhibitor

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2013.10.060 ◽

2013 ◽

Vol 23 (24) ◽

pp. 6585-6587 ◽

Cited By ~ 7

Author(s):

Qingbei Zeng ◽

Anilkumar G. Nair ◽

Stuart B. Rosenblum ◽

Hsueh-Cheng Huang ◽

Charles A. Lesburg ◽

...

Keyword(s):

Polymerase Inhibitor ◽

Hcv Ns5b ◽

P19: IDX21437, a novel nucleotide analogue prodrug HCV NS5B polymerase inhibitor

Journal of Viral Hepatitis ◽

10.1111/jvh.12333_18 ◽

2014 ◽

Vol 21 ◽

pp. 31-32

Keyword(s):

Nucleotide Analogue ◽

Polymerase Inhibitor ◽

Hcv Ns5b ◽

Synthesis of an HCV NS5B Polymerase Inhibitor

Synfacts ◽

10.1055/s-0031-1290308 ◽

2012 ◽

Vol 8 (04) ◽

pp. 0357-0357

Keyword(s):

Polymerase Inhibitor ◽

Hcv Ns5b ◽

Aza follow-ups to BI 207524, a thumb pocket 1 HCV NS5B polymerase inhibitor. Part 1: Mitigating the genotoxic liability of an aniline metabolite

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2014.12.028 ◽

2015 ◽

Vol 25 (5) ◽

pp. 1135-1139 ◽

Cited By ~ 6

Author(s):

Pierre L. Beaulieu ◽

Gordon Bolger ◽

Martin Duplessis ◽

Alexandre Gagnon ◽

Michel Garneau ◽

...

Keyword(s):

Polymerase Inhibitor ◽

Hcv Ns5b ◽