Abnormal PI3 kinase/Akt signal pathway in vagal afferent neurons and vagus nerve of streptozotocin-diabetic rats

2003 ◽  
Vol 110 (2) ◽  
pp. 234-244 ◽  
Author(s):  
Fang Cai ◽  
Cinda J Helke
Keyword(s):  
Vagus Nerve ◽  
Diabetic Rats ◽  
Signal Pathway ◽  
Pi3 Kinase ◽  
Afferent Neurons ◽  
Streptozotocin Diabetic Rats ◽  
Vagal Afferent

Progressive and concurrent deterioration of vagus-stimulated and hypoglycemia-induced glucagon secretion in streptozotocin-diabetic rats

1992 ◽  
Vol 126 (1) ◽  
pp. 80-84 ◽  
Author(s):  
Zsolt I Hertelendy ◽  
DG Patel ◽  
Kenneth A Skau
Keyword(s):  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Parasympathetic Nervous System ◽  
Matched Control ◽  
Streptozotocin Diabetes ◽  
Glucagon Secretion ◽  
Diabetic Rats ◽  
Male Rats ◽  
Streptozotocin Diabetic Rats

The effects of left cervical vagus nerve stimulation on glucagon secretion were studied in streptozotocin-diabetic and age-matched control adult male rats. At two-week intervals, after the induction of streptozotocin-diabetes, streptozotocin-diabetic and age-matched control rats were anesthetized with chloral hydrate (350 mg/kg, ip). Left cervical vagus nerves were electrically stimulated via a Grass stimulator with 5-volt monophasic pulses of 3 msec duration at a frequency of 20 Hz for 1, 2, and 4 min. Arginine-induced glucagon secretion was also determined. Vagus nerve-stimulated (2 and 4 min) glucagon secretion deteriorated as the duration of streptozotocin-diabetes increased. Glucagon secretion in response to vagus nerve stimulation was virtually absent by 12 weeks of streptozotocin-diabetes. However, arginine-induced glucagon secretion was unaffected. Subsequent experiments showed that the defect in glucagon secretion from vagal stimulation occurred concurrently with that seen from insulin-induced hypoglycemia. These results indicate that the impaired hypoglycemia-induced glucagon secretion in long-term streptozotocin-diabetic rats may be correlated with the deterioration of the parasympathetic nervous system transmission in streptozotocin-diabetes.

scholarly journals Decreased activity of the heparan sulfate-modifying enzyme glucosaminyl N-deacetylase in hepatocytes from streptozotocin-diabetic rats

1991 ◽  
Vol 266 (14) ◽  
pp. 8671-8674
Author(s):  
E. Unger ◽  
I. Pettersson ◽  
U.J. Eriksson ◽  
U. Lindahl ◽  
L. Kjellén
Keyword(s):  
Heparan Sulfate ◽  
Diabetic Rats ◽  
Streptozotocin Diabetic Rats
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