Contractile responses and calcium mobilization induced by muscarinic agonists in the rat urinary bladder: Effects of age

1997 ◽  
Vol 28 (4) ◽  
pp. 623-628 ◽  
Author(s):  
Hong-Jeng Yu ◽  
Alan J. Wein ◽  
Robert M. Levin
2006 ◽  
Vol 5 (2) ◽  
pp. 79
Author(s):  
S.C. Myung ◽  
M.Y. Lee ◽  
M.K. Lee ◽  
S.H. Ahn ◽  
T.H. Kim ◽  
...  

1963 ◽  
Vol 204 (4) ◽  
pp. 727-731 ◽  
Author(s):  
F. G. Carpenter

Electrical stimulation of an isolated rat urinary bladder in tris buffered Ringer's solution by coaxial electrodes elicits contractile responses amounting to 70–130 cm of water pressure. If the Ringer's solution is replaced by isotonic K2SO4 solution, pressures of 60–110 cm water pressure are developed. Responses elicited by low stimulating frequencies (.5–2.5/sec) and by K2SO4 are potentiated by physostigmine, however, 2 mg/liter atropine throughout the entire frequency range of .5–10/sec is without effect. The stimulating actions of K2SO4 and electrical stimuli are dependent upon the availability of Ca++. Responses to electric stimuli are believed to be mediated by way of cholinergic neural elements, those from K+ by a depolarization of the muscle fibers. To a more limited extent the contractile responses resulting from acetylcholine (ACh) are dependent upon Ca++ and contractures are also produced by ACh in bladders suspended in isotonic K2SO4. Conversely, electrical pulses or K2SO4 are effective stimuli in the presence of quantities of ACh or carbamylcholine sufficient to produce maximal responses. This suggests a different site of action for exogenous ACh as opposed to endogenous mediator released from cholinergic motor nerve terminals during motor nerve stimulation.


2017 ◽  
Vol 809 ◽  
pp. 253-260 ◽  
Author(s):  
Johanna Stenqvist ◽  
Michael Winder ◽  
Thomas Carlsson ◽  
Patrik Aronsson ◽  
Gunnar Tobin

2007 ◽  
Vol 570 (1-3) ◽  
pp. 182-187 ◽  
Author(s):  
Chikashi Saitoh ◽  
Chika Kitada ◽  
Wataru Uchida ◽  
Michael B. Chancellor ◽  
William C. de Groat ◽  
...  

Pharmacology ◽  
2010 ◽  
Vol 86 (5-6) ◽  
pp. 281-286
Author(s):  
Naoko Shimizu ◽  
Tsutomu Nakahara ◽  
Yuko Kubota ◽  
Kenji Sakamoto ◽  
Kunio Ishii

1992 ◽  
Vol 41 (3) ◽  
pp. 243
Author(s):  
Takashi Morita ◽  
Shun Kondo ◽  
Yohtalou Tashima ◽  
Kazunori Kihara ◽  
Masao Ando ◽  
...  

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