Rapid, sensitive gas chromatographic analysis of 8-methoxypsoralen in human plasma

1978 ◽  
Vol 146 (3) ◽  
pp. 498-502 ◽  
Author(s):  
Jochen Schmid ◽  
Friedrich Wilhelm Koss
Keyword(s):  
Human Plasma ◽  
Chromatographic Analysis ◽  
Gas Chromatographic Analysis

Gas chromatographic analysis of sodium di-n-propylacetate in human plasma

1978 ◽  
Vol 160 (1) ◽  
pp. 285-287 ◽  
Author(s):  
Jean-Claude Libeer ◽  
Simon Scharpé ◽  
Paul Schepens ◽  
Robert Verkerk
Keyword(s):  
Human Plasma ◽  
Chromatographic Analysis ◽  
Gas Chromatographic Analysis

scholarly journals Gas-chromatographic analysis for phencyclidine in plasma, with use of a nitrogen detector.

1980 ◽  
Vol 26 (3) ◽  
pp. 437-440
Author(s):  
D N Bailey ◽  
J J Guba
Keyword(s):  
Human Plasma ◽  
Chromatographic Analysis ◽  
Internal Standard ◽  
Amyl Alcohol ◽  
Gas Chromatographic Analysis ◽  
Coefficients Of Variation ◽  
One Year

Abstract We describe a reliable gas-chromatographic analysis for unchanged phencyclidine in human plasma, with use of a nitrogen detector. The assay is sufficiently sensitive to permit measurement of as little as 5 microgram of the drug per liter, in 2 mL of plasma. Phencyclidine is extracted from plasma at pH 10.5 into hexane/iso-amyl alcohol containing meperidine as the internal standard, back-extracted into dilute HCl, and re-extracted into hexane/iso-amyl alcohol after alkalinization of the HCl. The coefficients of variation for the analysis at respective concentrations of 100 and 200 microgram/L are: within-run 4.0% and 3.4%; between-run, 2.8% and 5.2%. This procedure, used in our laboratory for more than one year, has been applied to plasma from numerous individuals with nonfatal phencyclidine intoxication. Some representative examples are given.

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