Reversed-phase high-performance liquid chromatographic determination of verofylline in rat serum

1986 ◽  
Vol 382 ◽  
pp. 207-213 ◽  
Author(s):  
Linyee Shum ◽  
William J. Jusko
Keyword(s):  
High Performance ◽  
Chromatographic Determination ◽  
High Performance Liquid Chromatographic ◽  
Reversed Phase ◽  
Rat Serum ◽  
Liquid Chromatographic Determination ◽  
Liquid Chromatographic

REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC DETERMINATION OF CEFIXIME IN BULK DRUGS

2001 ◽  
Vol 24 (15) ◽  
pp. 2315-2324 ◽  
Author(s):  
Rolando González-Hernández ◽  
Lauro Nuevas-Paz ◽  
Laritza Soto-Mulet ◽  
Miguel López-López ◽  
Joseph Hoogmartens
Keyword(s):  
High Performance ◽  
Chromatographic Determination ◽  
High Performance Liquid Chromatographic ◽  
Reversed Phase ◽  
Liquid Chromatographic Determination ◽  
Liquid Chromatographic

Liquid-chromatographic determination of 5-fluorocytosine.

1980 ◽  
Vol 26 (1) ◽  
pp. 117-119
Author(s):  
J O Miners ◽  
T Foenander ◽  
D J Birkett
Keyword(s):  
High Performance ◽  
Chromatographic Determination ◽  
High Performance Liquid Chromatographic ◽  
Reversed Phase ◽  
Therapeutic Monitoring ◽  
Pharmacokinetic Studies ◽  
Liquid Chromatographic Method ◽  
Liquid Chromatographic Determination ◽  
Liquid Chromatographic

Abstract We report a "high-performance" liquid-chromatographic method for measuring 5-fluorocytosine in plasma and cerebrospinal fluid. After deproteinization with trichloroacetic acid, the supernates are chromatographed on a reversed-phase (C18) column. Response to concentration is linear in the range of 5 to 200 mg/L, with ultraviolet detection at 276 nm. The assay requires only 0.1 mL of plasma, is reproducible, and may be performed in less than 12 min. 5-Fluorocytosine concentrations determined by this procedure correlated well with those obtained by spectrofluorometry, although the present method is more specific with no observable interference from co-administered amphotericin B and most other commonly encountered drugs, including salicylat:. This method is applicable to the routine therapeutic monitoring of pediatric and adult patients as well as to pharmacokinetic studies.

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