Cochlear aqueduct flow resistance is not constant during evoked inner ear pressure change in the guinea pig

2003 ◽  
Vol 175 (1-2) ◽  
pp. 190-199 ◽  
Author(s):  
Hero P. Wit ◽  
Robert A. Feijen ◽  
Frans W.J. Albers
Keyword(s):  
Guinea Pig ◽  
Inner Ear ◽  
Flow Resistance ◽  
Pressure Change ◽  
Cochlear Aqueduct ◽  
Inner Ear Pressure

Dynamics of Inner Ear Pressure Change Caused by Intracranial Pressure Manipulation in the Guinea Pig

2001 ◽  
Vol 121 (4) ◽  
pp. 470-476 ◽  
Author(s):  
E.O. Thalen ◽  
H.P. Wit ◽  
J.M. Segenhout ◽  
F.W.J. Albers
Keyword(s):  
Intracranial Pressure ◽  
Guinea Pig ◽  
Inner Ear ◽  
Pressure Change ◽  
Inner Ear Pressure

Dynamics of Inner Ear Pressure Change Caused by Intracranial Pressure Manipulation in the Guinea Pig

2001 ◽  
Vol 121 (4) ◽  
pp. 470-476 ◽  
Author(s):  
E.O. Thalen ◽  
H.P. Wit ◽  
J.M. Segenhout ◽  
F.W.J. Albers
Keyword(s):  
Intracranial Pressure ◽  
Guinea Pig ◽  
Inner Ear ◽  
Pressure Change ◽  
Inner Ear Pressure

Relationship of the Cochlear Aqueduct and Inner Ear Pressure in M??ni??re's Disease and in a Normal Population

2001 ◽  
Vol 22 (4) ◽  
pp. 534-538 ◽  
Author(s):  
Cuneyt Yilmazer ◽  
Levent Sennaroglu ◽  
Figen Basaran ◽  
Gonca Sennaroglu
Keyword(s):  
Inner Ear ◽  
Normal Population ◽  
Cochlear Aqueduct ◽  
Relationship Of ◽  
Inner Ear Pressure

Dynamics of inner ear pressure release, measured with a double-barreled micropipette in the guinea pig

1999 ◽  
Vol 132 (1-2) ◽  
pp. 131-139 ◽  
Author(s):  
Hero P. Wit ◽  
Elisabeth O. Thalen ◽  
Frans W.J. Albers
Keyword(s):  
Guinea Pig ◽  
Inner Ear ◽  
Pressure Release ◽  
Inner Ear Pressure

scholarly journals The Estimation of the Time Constant of the Human Inner Ear Pressure Change by Noninvasive Technique

2009 ◽  
Vol 2009 ◽  
pp. 1-8 ◽  
Author(s):  
Raghida Traboulsi ◽  
Georges Poumarat ◽  
Jean Chazal ◽  
Paul Avan ◽  
Thierry Mom ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Intracranial Pressure ◽  
Inner Ear ◽  
Time Constant ◽  
Otoacoustic Emissions ◽  
Pressure Change ◽  
Noninvasive Technique ◽  
Cochlear Aqueduct ◽  
Distortion Product ◽  
Long Time

We propose a noninvasive method to estimate the time constant. The calculation of this factor permits us to understand the pressure variations of the inner ear and also predict the behavior of the flow resistance of the cochlear aqueduct. A set of mathematical relationships incorporating the intralabyrinthine pressure, the intracranial pressure, and the time constant was applied. The modeling process describes the hydrodynamic effects of the cerebrospinal fluid in the intralabyrinthine fluid space, where the input and output of the created model are, respectively, the sinusoidal variation of the respiration signal and the distortion product of otoacoustic emissions. The obtained results were compared with those obtained by different invasive techniques. A long time constant was detected each time when the intracranial pressure increased; this phenomenon is related to the role of the cochlear aqueduct described elsewhere. The interpretation of this model has revealed the ability of these predictions to provide a greater precision for hydrodynamic variation of the inner ear, consequently the variation of the dynamic process of the cerebrospinal fluid.

Change of Guinea Pig Inner Ear Pressure by Square Wave Middle Ear Cavity Pressure Variation

2002 ◽  
Vol 122 (2) ◽  
pp. 138-145 ◽  
Author(s):  
R. A. Feijen ◽  
J. M. Segenhout ◽  
F. W. J. Albers ◽  
H. P. Wit
Keyword(s):  
Guinea Pig ◽  
Inner Ear ◽  
Middle Ear ◽  
Pressure Variation ◽  
Cavity Pressure ◽  
Square Wave ◽  
Inner Ear Pressure

scholarly journals Changes in CMDP and DPOAE during acute increased inner ear pressure in the guinea pig

2007 ◽  
Vol 265 (3) ◽  
pp. 287-292 ◽  
Author(s):  
W. L. Valk ◽  
H. P. Wit ◽  
F. W. J. Albers
Keyword(s):  
Guinea Pig ◽  
Inner Ear ◽  
Inner Ear Pressure

scholarly journals Intracochlear Drug Injections through the Round Window Membrane: Measures to Improve Drug Retention

2016 ◽  
Vol 21 (2) ◽  
pp. 72-79 ◽  
Author(s):  
Stefan K. Plontke ◽  
Jared J. Hartsock ◽  
Ruth M. Gill ◽  
Alec N. Salt
Keyword(s):  
Inner Ear ◽  
Round Window ◽  
Fluorescein Isothiocyanate ◽  
Oval Window ◽  
Round Window Membrane ◽  
Fluid Exchange ◽  
Cochlear Aqueduct ◽  
Quantitative Manner ◽  
Almost All ◽  
Inner Ear Pressure

The goal of this study was to develop an appropriate methodology to apply drugs quantitatively to the perilymph of the ear. Intratympanic applications of drugs to the inner ear often result in variable drug levels in the perilymph and can only be used for molecules that readily permeate the round window (RW) membrane. Direct intracochlear and intralabyrinthine application procedures for drugs, genes or cell-based therapies bypass the tight boundaries at the RW, oval window, otic capsule and the blood-labyrinth barrier. However, perforations can release inner ear pressure, allowing cerebrospinal fluid (CSF) to enter through the cochlear aqueduct, displacing the injected drug solution into the middle ear. Two markers, fluorescein or fluorescein isothiocyanate-labeled dextran, were used to quantify how much of an injected substance was retained in the cochlear perilymph following an intracochlear injection. We evaluated whether procedures to mitigate fluid leaks improved marker retention in perilymph. Almost all procedures to reduce volume efflux, including the use of gel for internal sealing and glue for external sealing of the injection site, resulted in improved retention of the marker in perilymph. Adhesive on the RW membrane effectively prevented leaks but also influenced fluid exchange between CSF and perilymph. We conclude that drugs can be delivered to the ear in a consistent, quantitative manner using intracochlear injections if care is taken to control the fluid leaks that result from cochlear perforation.

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