scholarly journals Acute hyperglycemia abolishes ischemic preconditioning: A possible mechanism for adverse outcome of patients with acute myocardial infarction and acute hyperglycemia

2003 ◽  
Vol 41 (6) ◽  
pp. 345
Author(s):  
Masaharu Ishihara ◽  
Ichiro Inoue ◽  
Takuji Kawagoe ◽  
Yuji Shimatani ◽  
Satoshi Kurisu ◽  
...  
2005 ◽  
Vol 150 (4) ◽  
pp. 814-820 ◽  
Author(s):  
Masaharu Ishihara ◽  
Sunao Kojima ◽  
Tomohiro Sakamoto ◽  
Yujiro Asada ◽  
Chuwa Tei ◽  
...  

1999 ◽  
Vol 82 (S 01) ◽  
pp. 68-72 ◽  
Author(s):  
Alessandro Sciahbasi ◽  
Eugenia De Marco ◽  
Attilio Maseri ◽  
Felicita Andreotti

SummaryPreinfarction angina and early reperfusion of the infarct-related artery are major determinants of reduced infarct-size in patients with acute myocardial infarction. The beneficial effects of preinfarction angina on infarct size have been attributed to the development of collateral vessels and/or to post-ischemic myocardial protection. However, recently, a relation has been found between prodromal angina, faster coronary recanalization, and smaller infarcts in patients treated with rt-PA: those with preinfarction angina showed earlier reperfusion (p = 0.006) and a 50% reduction of CKMB-estimated infarct-size (p = 0.009) compared to patients without preinfarction angina. This intriguing observation is consistent with a subsequent observation of higher coronary recanalization rates following thrombolysis in patients with prodromal preinfarction angina compared to patients without antecedent angina. Recent findings in dogs show an enhanced spontaneous lysis of plateletrich coronary thrombi with ischemic preconditioning, which is prevented by adenosine blockade, suggesting an antithrom-botic effect of ischemic metabolites. Understanding the mechanisms responsible for earlier and enhanced coronary recanalization in patients with preinfarction angina may open the way to new reperfusion strategies.A vast number of studies, globally involving ≈17,000 patients with acute myocardial infarction, have unequivocally shown that an infarction preceded by angina evolves into a smaller area of necrosis compared to an infarct not preceded by angina (Table 1) (1). So far, preinfarction angina has been thought to have cardioprotective effects mainly through two mechanisms: collateral perfusion of the infarctzone (2-4), and ischemic preconditioning of the myocardium (5-7). Here we discuss a further mechanism of protection represented by improved reperfusion of the infarct-related artery.


2014 ◽  
Vol 176 (3) ◽  
pp. 1214-1216 ◽  
Author(s):  
Masaaki Konishi ◽  
Eiichi Akiyama ◽  
Yasushi Matsuzawa ◽  
Hiroyuki Suzuki ◽  
Nobuhiko Maejima ◽  
...  

2003 ◽  
Vol 33 (5) ◽  
pp. 374
Author(s):  
Cheol Hong Kim ◽  
Kyu Hyung Ryu ◽  
Jin Won Jo ◽  
Ji Hyun Hong ◽  
Seong Woo Han ◽  
...  

2000 ◽  
Vol 140 (5) ◽  
pp. 740-746 ◽  
Author(s):  
Khalid Barakat ◽  
Paul Wilkinson ◽  
Abdul Suliman ◽  
Kulasegaram Ranjadayalan ◽  
Adam Timmis

Esculapio ◽  
2021 ◽  
Vol 17 (1) ◽  
pp. 5-8
Author(s):  
Rizwan Abbas ◽  
Tazeen Nazar ◽  
Bilal Aziz ◽  
Furqan Saeed ◽  
Kashif Nawaz ◽  
...  

Objective: To determine the effect of serum potassium levels on short term mortality outcomes in patients with acute myocardial infarction. Methods: This Descriptive Case Series was conducted in the CCU of Mayo Hospital Lahore from 15th November, 2017 to 15th May, 2018. A total of 156 patients of either sex between the age group of 30-60 years and diagnosed as cases of myocardial infarction with symptoms of less than 24 hours duration and serum potassium level of <3.5 mEq/L were included in the study. Patients were then followed up for 7 days and adverse outcome was recorded. Data was analyzed using computer software SPSS Version 22.0. Results: Out of the 156 patients, 119 (76.3%) were males and 37 (23.7%) were females. Mean age of the patients was 47.88±6.24 years, mean weight 85.31±13.14 Kg, mean duration of presenting complaints was 10.269±4.51 hours and mean Serum Potassium levels were 3.05±0.25 mEq/L. Adverse outcome in the form of mortality due to arrhythmias was seen in 15 (9.6%) patients. Conclusion: Low serum potassium level (<3.5mEq/L/L) was significantly associated with increased adverse outcome in acute myocardial infarction patients. Keywords: Acute myocardial infarction, Low serum potassium levels, Adverse outcome How to cite: Abbas R., Nazar T, Aziz B., Saeed F., Nawaz K., Nabeel M. serum potassium levels and adverse outcomes in patients with acute myocardial infarction. Esculapio 2021;17(01):5-8


2018 ◽  
Vol 10 (1) ◽  
pp. 16
Author(s):  
M. Hassine ◽  
M. Boussaada ◽  
M. Ben Massoued ◽  
O. Laabidi ◽  
M. Mahjoub ◽  
...  

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